Biocompatibility of Doped Diamond-Like Carbon Coatings for Medical Implants

被引：35

作者：

Thorwarth, Goetz ^{[1
]}

Saldamli, Belma ^{[2
]}

Schwarz, Florian ^{[1
]}

Juergens, Philipp ^{[2
]}

Leiggener, Christoph ^{[2
]}

Sader, Robert ^{[3
]}

Haeberlen, Maik ^{[1
]}

Assmann, Walter ^{[4
,5
]}

Stritzker, Bernd ^{[1
]}

机构：

[1] Univ Augsburg, Inst Phys, Lehrstuhl Expt Phys 4, D-86135 Augsburg, Germany

[2] Univ Basel Hosp, Dept Craniomaxillofacial Surg, Basel, Switzerland

[3] Goethe Univ Frankfurt, Clin Craniomaxillofacial Surg, Frankfurt, Germany

[4] LMU, MLL Beschleunigerlab, D-85748 Garching, Germany

[5] Tech Univ Munich, D-85748 Garching, Germany

来源：

PLASMA PROCESSES AND POLYMERS | 2007年 / 4卷

关键词：

biocompatibility; cell culture tests; coatings; diamond-like carbon (DLC); doping; PIII&D; surfaces;

D O I：

10.1002/ppap.200731001

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Diamond-like carbon (DLC) has been established as a very favourable coating for joint prosthetics due to its low friction, high corrosion resistance and biocompatibility. The addition of dopants allows for the modification of several physical properties of DLC, whose relations to biocompatibility have not yet been thoroughly investigated. We studied the properties of a-C:H layers deposited on TiAl6V4 by the plasma immersion ion implantation and deposition (PIII&D) technique. Physical analysis performed comprises the range of attainable compositions [obtained by Rutherford backscattering spectroscopy (RBS) and elastic recoil detection analysis (ERDA)] and structures [by Raman Spectroscopy and energy filtered transmission electron microscopy (EFTEM)] for the cases of the dopants N, Si and TiOx. The biocompatibility assessments were performed in vitro, utilizing human osteoblasts. Cellular proliferation was measured by means of DNA quantification. Osteogenic differentiation was investigated by screening alkaline phosphatase activity and mineralization of cultures. The results demonstrate that highly biocompatible and wear-resistant coatings on complex formed implant surfaces can be efficiently fabricated utilizing PIII&D.

引用

页码：S364 / S368

页数：5

共 23 条

[1]

Anders A., 2000, HDB PLASMA IMMRSION

[2] Synthesis and properties of TiO2 thin films by plasma source ion implantation [J].

Baba, K ;

Hatada, R .

SURFACE & COATINGS TECHNOLOGY, 2001, 136 (1-3) :241-243

[3] Preparation and properties of nitrogen and titanium oxide incorporated diamond-like carbon films by plasma source ion implantation [J].

Baba, K ;

Hatada, R .

SURFACE & COATINGS TECHNOLOGY, 2001, 136 (1-3) :192-196

[4]

Baier R E, 1999, Semin Vasc Surg, V12, P8

[5]

BAIER RE, 1992, OPER DENT, P1

[6] Tribological study of lubricious DLC biocompatible coatings [J].

Brizuela, M ;

Garcia-Luis, A ;

Viviente, JL ;

Braceras, I ;

Oñate, JI .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2002, 13 (12) :1129-1133

[7] Diamond-like carbon:: alteration of the biological acceptance due to Ca-O incorporation [J].

Dorner-Reisel, A ;

Schürer, C ;

Nischan, C ;

Seidel, O ;

Müller, E .

THIN SOLID FILMS, 2002, 420 :263-268

[8] Characterization of surface oxide films on titanium and adhesion of osteoblast [J].

Feng, B ;

Weng, J ;

Yang, BC ;

Qu, SX ;

Zhang, XD .

BIOMATERIALS, 2003, 24 (25) :4663-4670

[9] Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro [J].

Frank, O ;

Heim, M ;

Jakob, M ;

Barbero, A ;

Schäfer, D ;

Bendik, I ;

Dick, W ;

Heberer, M ;

Martin, I .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, 85 (04) :737-746

[10] Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells [J].

Gronthos, S ;

Zannettino, ACW ;

Graves, SE ;

Ohta, S ;

Hay, SJ ;

Simmons, PJ .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (01) :47-56

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