Synthesis and Anticancer Activity of Novel 1,2,3-Triazole Ring Incorporated 1,2,4-Oxadiazole-1,3-Oxazole Derivatives

被引：6

作者：

Krishna, Radha ^{[1
]}

Sridhar, G. ^{[2
,3
]}

Jayaprakash, H. V. ^{[1
]}

机构：

[1] Siddhartha Acad Higher Educ, Sri Siddhartha Inst Technol, Dept Chem, Tumkur 572105, Karnataka, India

[2] CSIR Indian Inst Chem Technol, Organ & Biomol Chem Div, Hyderabad 500107, Telangana, India

[3] Kakatiya Inst Technol & Sci, Dept Chem, Warangal 506015, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 05期

关键词：

inthomycin C; synthesis; 1; 3-oxazole derivatives; anti-cancer activity; INHIBITORS; DISCOVERY; DESIGN; POTENT;

D O I：

10.1134/S1070363220050242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of novel 1,2,3-triazole incorporated 1,2,4-oxadiazole-1,3-oxazole derivatives has been synthesised, and the molecular structures are confirmed by(1)H and(13)C NMR and mass spectra. All the derivatives have been tested against four human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-2-5 (colon), and A2780 (ovarian) using etoposide as a positive control. Five compounds have demonstrated potent anticancer activity, and two of those are characterised as highly active.

引用

页码：901 / 906

页数：6

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