The Use of Antifungal Therapy in Neonatal Intensive Care

被引：16

作者：

Testoni, Daniela ^{[1
]}

Smith, P. Brian ^{[1
,2
]}

Benjamin, Daniel K., Jr. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27705 USA

[2] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

来源：

CLINICS IN PERINATOLOGY | 2012年 / 39卷 / 01期

关键词：

Invasive candidiasis; Amphotericin B deoxycholate; Flucytosine; Fluconazole; Voriconazole; Posaconazole; Micafungin; Anidulafungin; Caspofungin; LIPOSOMAL AMPHOTERICIN-B; INVASIVE FUNGAL-INFECTIONS; MULTIPLE-DOSE PHARMACOKINETICS; IN-VITRO ACTIVITIES; FLUCONAZOLE PROPHYLAXIS; DOUBLE-BLIND; POPULATION PHARMACOKINETICS; PEDIATRIC-PATIENTS; HIGH-RISK; INTRAVENOUS ANIDULAFUNGIN;

D O I：

10.1016/j.clp.2011.12.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Invasive fungal infections remain a significant cause of infection-related mortality and morbidity in preterm infants. Central nervous system involvement is the hallmark of neonatal candidiasis, differentiating the disease's impact on young infants from that among all other patient populations. Over the past decade, the number of antifungal agents in development has grown, but most are not labeled for use in newborns. We summarize the findings of several antifungal studies that have been completed to date, emphasizing those including infant populations. We conclude that more studies are required for antifungals to be used safely and effectively in infants.

引用

页码：83 / +

页数：17

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