Recent developments in the discovery of selective glucocorticoid receptor modulators (SGRMs)

被引：28

作者：

Hudson, Andrew R. ^{[1
]}

Roach, Steven L. ^{[1
]}

Higuchi, Robert I. ^{[1
]}

机构：

[1] Ligand Pharmaceut, Discovery Res, San Diego, CA 92121 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 09期

关键词：

SGRM; glucocorticoid; nonsteroidal; modulator; transactivation; transrepression; dissociated; inflammation; multiple myeloma;

D O I：

10.2174/156802608784535048

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.

引用

页码：750 / 765

页数：16

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