Shape and volume of Lacunar Infarcts -: A 3D MRI study in cerebral autosomal dominant arteriopathy with subcortical Infarcts and leukoencephalopathy

被引:49
作者
Hervé, D
Mangin, JF
Molko, N
Bousser, MG
Chabriat, H
机构
[1] Hop Lariboisiere, Serv Neurol, F-75010 Paris, France
[2] CEA, Serv Hosp Frederic Joliot, 2INSERM, U562, F-91406 Orsay, France
[3] CEA, Serv Hosp Frederic Joliot, Inst Federat Rech 49, F-91406 Orsay, France
关键词
CADASIL syndrome; diagnostic methods; lacunar infarcts; MRI;
D O I
10.1161/01.STR.0000185678.26296.38
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose - The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients. Methods - We segmented 102 lacunar infarcts on T1-weighted images. The surface of the corresponding set of voxels was computed as a mesh of triangles. Thereafter, the shape of each lesion in 3D was visually analyzed by 2 investigators. Results - The volume of lesions ranged from 10.5 to 1146 mm, with 93% of them having a volume <500 mm; 83% lacunar infarcts had a spheroid or ovoid shape, but 17% presented as sticks, slabs, or with a complex shape. Lesions with multiple components appeared larger than the others, and a tail extension was noticed in 13 of 102 lesions. Conclusions - These results suggest the following: (1) most lacunar infarcts in CADASIL have a volume far below one third of that of a sphere of 15 mm in diameter, the upper limit currently used for their identification on 2D imaging; (2) a significant proportion of lacunar infarcts have a shape distinct from the spheroid-ovoid morphology; and (3) lesions with a complex shape may result from the involvement of the largest small arteries, confluence of ischemic lesions, or secondary tissue degeneration. The segmentation of lacunar infarcts appears promising to better understand the pathophysiology of tissue lesions secondary to small vessel diseases.
引用
收藏
页码:2384 / 2388
页数:5
相关论文
共 28 条
[1]   Distinguishing silent lacunar infarction from enlarged Virchow-Robin spaces: a magnetic resonance imaging and pathological study [J].
Bokura, H ;
Kobayashi, S ;
Yamaguchi, S .
JOURNAL OF NEUROLOGY, 1998, 245 (02) :116-122
[2]   BRAIN MR - PATHOLOGIC CORRELATION WITH GROSS AND HISTOPATHOLOGY .1. LACUNAR INFARCTION AND VIRCHOW-ROBIN SPACES [J].
BRAFFMAN, BH ;
ZIMMERMAN, RA ;
TROJANOWSKI, JQ ;
GONATAS, NK ;
HICKEY, WF ;
SCHLAEPFER, WW .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1988, 151 (03) :551-558
[3]   Patterns of MRI lesions in CADASIL [J].
Chabriat, H ;
Levy, C ;
Taillia, H ;
Iba-Zizen, MT ;
Vahedi, K ;
Joutel, A ;
Tournier-Lasserve, E ;
Bousser, MG .
NEUROLOGY, 1998, 51 (02) :452-457
[4]   CLINICAL SPECTRUM OF CADASIL - A STUDY OF 7 FAMILIES [J].
CHABRIAT, H ;
VAHEDI, K ;
IBAZIZEN, MT ;
JOUTEL, A ;
NIBBIO, A ;
NAGY, TG ;
KREBS, MO ;
JULIEN, J ;
DUBOIS, B ;
DUCROCQ, X ;
LEVASSEUR, M ;
HOMEYER, P ;
MAS, JL ;
LYONCAEN, O ;
LASSERVE, ET ;
BOUSSER, MG .
LANCET, 1995, 346 (8980) :934-939
[5]  
DECHAMBRE A, 1838, GAZ MED PARIS, V6, P305
[6]  
Durand-Fardel M., 1842, GAZ MED PARIS, V10, P23
[7]  
FISHER CM, 1991, CEREBROVASC DIS, V1, P311
[8]   PURE MOTOR HEMIPLEGA OF VASCULAR ORIGIN [J].
FISHER, CM ;
CURRY, HB .
ARCHIVES OF NEUROLOGY, 1965, 13 (01) :30-&
[9]   LACUNES - SMALL DEEP CEREBRAL INFARCTS [J].
FISHER, CM .
NEUROLOGY, 1965, 15 (08) :774-&
[10]   ATAXIC HEMIPARESIS - PATHOLOGIC-STUDY [J].
FISHER, CM .
ARCHIVES OF NEUROLOGY, 1978, 35 (03) :126-128