HIV eradication symposium: will the brain be left behind?

被引：15

作者：

Brew, B. J. ^{[1
,2
,3
]}

Robertson, K. ^{[4
]}

Wright, E. J. ^{[5
]}

Churchill, M. ^{[7
]}

Crowe, S. M. ^{[5
]}

Cysique, L. A. ^{[1
,2
,3
,6
]}

Deeks, S. ^{[8
]}

Garcia, J. V. ^{[9
]}

Gelman, B. ^{[10
]}

Gray, L. R. ^{[7
]}

Johnson, T. ^{[11
]}

Joseph, J. ^{[12
]}

Margolis, D. M. ^{[13
]}

Mankowski, J. L. ^{[14
,15
]}

Spencer, B. ^{[16
]}

机构：

[1] St Vincents Hosp, St Vincents Ctr Appl Med Res, Dept Neurol, Dept Immunol, Sydney, NSW 2010, Australia

[2] St Vincents Hosp, St Vincents Ctr Appl Med Res, Dept Infect Dis, Sydney, NSW 2010, Australia

[3] St Vincents Hosp, St Vincents Ctr Appl Med Res, Peter Duncan Neurosci Unit, Sydney, NSW 2010, Australia

[4] Univ N Carolina, Dept Neurol, Chapel Hill, NC USA

[5] Alfred Hosp Melbourne Australia, Dept Infect Dis, Melbourne, Vic, Australia

[6] NeuRA, Sydney, NSW, Australia

[7] Burnet Inst, Melbourne, Vic, Australia

[8] Univ Calif San Francisco, Dept Infect Dis, San Francisco, CA 94143 USA

[9] Univ N Carolina, Ctr AIDS Res, Div Infect Dis, Chapel Hill, NC USA

[10] Univ Texas Austin, Austin, TX 78712 USA

[11] NINDS, Sect Infect Nervous Syst, NIH, Bethesda, MD 20892 USA

[12] NIMH, Div AIDS Res, NIH, Bethesda, MD 20892 USA

[13] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[14] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

[15] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[16] Univ Calif San Diego, San Diego, CA 92103 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2015年 / 21卷 / 03期

关键词：

Human immunodeficiency virus type 1; Acquired immunodeficiency syndrome; HIV-associated neurocognitive disorders; Eradication; Brain; IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; CEREBROSPINAL-FLUID; IN-VIVO; RALTEGRAVIR INTENSIFICATION; SUPPRESSIVE THERAPY; LATENT HIV-1; REPLICATION-COMPETENT; REVERSE TRANSCRIPTION; SITU HYBRIDIZATION;

D O I：

10.1007/s13365-015-0322-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th International AIDS Conference. The meeting was held in Melbourne, Australia, and brought together investigators currently working on HIV eradication together with investigators who are working on the neurological complications of HIV. The purpose of the meeting was to bring the two fields of HIV eradication and HIV neurology together to foster dialogue and cross talk to move the eradication field forward in the context of issues relating to the brain as a potential reservoir of HIV. The outcomes of the symposium were that there was substantive but not definitive evidence for the brain as an HIV reservoir that will provide a challenge to HIV eradication. Secondly, the brain as a clinically significant reservoir for HIV is not necessarily present in all patients. Consequently, there is an urgent need for the development of biomarkers to identify and quantify the HIV reservoir in the brain. Lastly, when designing and developing eradication strategies, it is critical that approaches to target the brain reservoir be included.

引用

页码：322 / 334

页数：13

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