Detection and Isolation of Clostridium difficile Asymptomatic Carriers During Clostridium difficile Infection Outbreaks: An Exploratory Study

被引:11
作者
Paquet-Bolduc, Bianka [1 ]
Gervais, Philippe [1 ,2 ]
Roussy, Jean-Francois [1 ,2 ]
Trottier, Sylvie [1 ,2 ]
Oughton, Matthew [3 ,4 ]
Brukner, Ivan [3 ]
Longtin, Jean [2 ]
Loo, Vivian G. [4 ,5 ]
Dascal, Andre [3 ,4 ]
Longtin, Yves [3 ,4 ]
机构
[1] Quebec Heart & Lung Inst, Quebec City, PQ, Canada
[2] Univ Laval, Fac Med, Quebec City, PQ, Canada
[3] Jewish Gen Hosp, Montreal, PQ, Canada
[4] McGill Univ, Fac Med, Montreal, PQ, Canada
[5] McGill Univ, Hlth Ctr, Montreal, PQ, Canada
关键词
Clostridium difficile; asymptomatic carriers; colonization; screening; isolation precautions; HOSPITAL ADMISSION; TRANSMISSION;
D O I
10.1093/cid/ciy425
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During 4 Clostridium difficile infection outbreaks, unit-wide screening of 114 patients led to detection and isolation of 15 (13%) C. difficile asymptomatic carriers. Carriage prevalence varied between outbreaks, from 0% to 29% (P = .004). Isolating carriers was not associated with significantly shorter outbreak durations, compared with historical controls.
引用
收藏
页码:1781 / 1783
页数:3
相关论文
共 12 条
  • [1] Asymptomatic Carriers Contribute to Nosocomial Clostridium difficile Infection: A Cohort Study of 4508 Patients
    Blixt, Thomas
    Gradel, Kim Oren
    Homann, Christian
    Seidelin, Jakob Benedict
    Schonning, Kristian
    Lester, Anne
    Houlind, Jette
    Stangerup, Marie
    Gottlieb, Magnus
    Knudsen, Jenny Dahl
    [J]. GASTROENTEROLOGY, 2017, 152 (05) : 1031 - +
  • [2] Clostridium difficile skin contamination in patients with C-difficile-associated disease
    Bobulsky, Greg S.
    Al-Nassir, Wafa N.
    Riggs, Michelle M.
    Sethi, Ajay K.
    Donskey, Curtis J.
    [J]. CLINICAL INFECTIOUS DISEASES, 2008, 46 (03) : 447 - 450
  • [3] Colonization Versus Carriage of Clostridium difficile
    Donskey, Curtis J.
    Kundrapu, Sirisha
    Deshpande, Abhishek
    [J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2015, 29 (01) : 13 - +
  • [4] Dubberke ER, 2014, INFECT CONT HOSP EP, V35, P628, DOI [10.1017/S0899823X00193857, 10.1086/676023]
  • [5] Asymptomatic Clostridium difficile colonization in two Australian tertiary hospitals, 2012-2014: prospective, repeated cross-sectional study
    Furuya-Kanamori, L.
    Clements, A. C. A.
    Foster, N. F.
    Huber, C. A.
    Hong, S.
    Harris-Brown, T.
    Yakob, L.
    Paterson, D. L.
    Riley, T. V.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2017, 23 (01) : 48.e1 - 48.e7
  • [6] Active Surveillance and Isolation of Asymptomatic Carriers of Clostridium difficile at Hospital Admission Containing What Lies Under the Waterline
    Guh, Alice Y.
    McDonald, L. Clifford
    [J]. JAMA INTERNAL MEDICINE, 2016, 176 (06) : 805 - 806
  • [7] Institut National de Sante Publique du Quebec, PROT SURV DIARRH ASS
  • [8] Epidemiological Model for Clostridium difficile Transmission in Healthcare Settings
    Lanzas, C.
    Dubberke, E. R.
    Lu, Z.
    Reske, K. A.
    Groehn, Y. T.
    [J]. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2011, 32 (06) : 553 - 561
  • [9] Lessa FC, 2015, NEW ENGL J MED, V372, P2369, DOI [10.1056/NEJMoa1408913, 10.1056/NEJMc1505190]
  • [10] Longtin Y, 2016, JAMA INTERN MED, V176, P796, DOI [10.1001/jama, 10.1001/jamainternmed.2016.0177]