Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases

被引：172

作者：

Kaufmann, Timothy J. ^{[1
]}

Smits, Marion ^{[2
]}

Boxerman, Jerrold ^{[3
,4
]}

Huang, Raymond ^{[5
]}

Barboriak, Daniel P. ^{[6
]}

Weller, Michael ^{[7
,8
,9
]}

Chung, Caroline ^{[10
]}

Tsien, Christina ^{[11
]}

Brown, Paul D. ^{[12
]}

Shankar, Lalitha ^{[13
]}

Galanis, Evanthia ^{[14
]}

Gerstner, Elizabeth ^{[15
]}

van den Bent, Martin J. ^{[16
]}

Burns, Terry C. ^{[17
]}

Pamey, Ian F. ^{[17
]}

Dunn, Gavin ^{[18
]}

Brastianos, Priscilla K. ^{[19
,20
]}

Lin, Nancy U. ^{[21
]}

Wen, Patrick Y. ^{[22
]}

Ellingson, Benjamin M. ^{[23
,24
,25
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN USA

[2] Erasmus MC, Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[3] Brown Univ, Rhode Isl Hosp, Dept Diagnost Imaging, Providence, RI 02903 USA

[4] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA

[5] Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA

[6] Duke Univ, Sch Med, Dept Radiol, Durham, NC USA

[7] Univ Hosp, Dept Neurol, Zurich, Switzerland

[8] Univ Hosp, Brain Tumor Ctr, Zurich, Switzerland

[9] Univ Zurich, Zurich, Switzerland

[10] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[11] Johns Hopkins Univ, Dept Radiat Oncol, Baltimore, MD USA

[12] Mayo Clin, Dept Radiat Oncol, Rochester, MN USA

[13] NCI, Div Canc Treatment & Diag, Bethesda, MD 20892 USA

[14] Mayo Clin, Div Med Oncol, Dept Oncol, Rochester, MN USA

[15] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[16] Erasmus MC, Dept Neurooncol, Canc Inst, Rotterdam, Netherlands

[17] Mayo Clin, Dept Neurosurg, Rochester, MN USA

[18] Washington Univ, Dept Neurol Surg, St Louis, MO 63110 USA

[19] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[20] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[21] Harvard Med Sch, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[22] Harvard Med Sch, Dana Farber Brigham & Womens Canc Ctr, Ctr Neurooncol, Boston, MA 02115 USA

[23] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Comp Vis & Imaging Biomarkers, UCLA Brain Tumor Imaging Lab, Los Angeles, CA 90095 USA

[24] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiol Sci, Los Angeles, CA 90095 USA

[25] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA

来源：

NEURO-ONCOLOGY | 2020年 / 22卷 / 06期

关键词：

brain metastases; imaging; MRI; protocol; CONTRAST-ENHANCED MR; GAMMA-KNIFE RADIOSURGERY; MAGNETIC-RESONANCE SPECTROSCOPY; APPARENT DIFFUSION-COEFFICIENT; ATTENUATED INVERSION-RECOVERY; HIGH-DOSE GADOTERIDOL; RAPID GRADIENT-ECHO; SPIN-ECHO; STEREOTACTIC RADIOSURGERY; CEREBRAL METASTASES;

D O I：

10.1093/neuonc/noaa030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocacy groups to discuss challenges and potential solutions for increasing development of therapeutics for central nervous system metastases. A key issue identified at this meeting was the need for consistent tumor measurement for reliable tumor response assessment, including the first step of standardized image acquisition with an MRI protocol that could be implemented in multicenter studies aimed at testing new therapeutics. This document builds upon previous consensus recommendations for a standardized brain tumor imaging protocol (BTIP) in high-grade gliomas and defines a protocol for brain metastases (BTIP-BM) that addresses unique challenges associated with assessment of CNS metastases. The "minimum standard" recommended pulse sequences include: (i) parameter matched pre- and post-contrast inversion recovery (IR)-prepared, isotropic 3D T1-weighted gradient echo (IR-GRE); (ii) axial 2D T2-weighted turbo spin echo acquired after injection of gadolinium-based contrast agent and before post-contrast 3D T1-weighted images; (iii) axial 2D or 3D T2-weighted fluid attenuated inversion recovery; (iv) axial 2D, 3-directional diffusion-weighted images; and (v) post-contrast 2D T1-weighted spin echo images for increased lesion conspicuity. Recommended sequence parameters are provided for both 1.5T and 3T MR systems. An "ideal" protocol is also provided, which replaces IR-GRE with 3D TSE T1-weighted imaging pre- and post-gadolinium, and is best performed at 3T, for which dynamic susceptibility contrast perfusion is included. Recommended perfusion parameters are given.

引用

页码：757 / 772

页数：16

共 154 条

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