Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

被引：241

作者：

Hamdy, Samar ^{[1
]}

Haddadi, Azita ^{[2
]}

Hung, Ryan W. ^{[3
]}

Lavasanifar, Afsaneh ^{[1
,4
]}

机构：

[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Dent Pharm Ctr 3133, Edmonton, AB T6G 2N8, Canada

[2] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7N 0W0, Canada

[3] Univ Alberta, Fac Med, Dept Radiol & Diagnost Imaging, Edmonton, AB T6G 2N8, Canada

[4] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2N8, Canada

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2011年 / 63卷 / 10-11期

关键词：

Adjuvant; Cancer; Vaccine; PLGA; POLY(D; L-LACTIC-CO-GLYCOLIC ACID) MICROSPHERES; ANTIGEN CROSS-PRESENTATION; MACROPHAGES IN-VITRO; OF-THE-ART; IMMUNE-RESPONSES; BIODEGRADABLE MICROSPHERES; MELANOMA PATIENTS; TUMOR-IMMUNOTHERAPY; T-CELLS; PHASE-I;

D O I：

10.1016/j.addr.2011.05.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Development of safe and effective cancer vaccine formulation is a primary focus in the field of cancer immunotherapy. The recognition of the crucial role of dendritic cells (DCs) in initiating anti-tumor immunity has led to the development of several strategies that target vaccine antigens to DCs as an attempt for developing potent, specific and lasting anti-tumor T cell responses. The main objective of this review is to provide an overview on the application of poly (D,L-lactic-co-glycolic acid) nanoparticles (PLGA-NPs) as cancer vaccine delivery system and highlight their potential in the development of future therapeutic cancer vaccines. PLGA-NPs containing antigens along with immunostimulatory molecules (adjuvants) can not only target antigen actively to DCs, but also provide immune activation and rescue impaired DCs from tumor-induced immuosupression. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：943 / 955

页数：13

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