Iron-Catalyzed Azidoalkylthiation of Alkenes with Trimethylsilyl Azide and 1-(Alkylthio)pyrrolidine-2,5-diones

被引：19

作者：

Yu, Jipan ^{[1
]}

Jiang, Min ^{[1
]}

Song, Zhixuan ^{[1
]}

He, Tiancheng ^{[1
]}

Yang, Haijun ^{[1
]}

Fu, Hua ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 17期

基金：

中国国家自然科学基金;

关键词：

alkylthiation; azidation; difunctionalization; iron-catalyzed reaction; synthetic methods; C-H SULFENYLATION; MECHANISTIC PATHWAYS; BOND FORMATION; OXINDOLE DERIVATIVES; ALKYNE CYCLOADDITION; CONJUGATED DIENES; PALLADIUM; DIAMINATION; REACTIVITY; ACIDS;

D O I：

10.1002/adsc.201600133

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple, efficient and practical iron-catalyzed azidoarylthiation of alkenes has been developed at room temperature, and the corresponding products containing ortho-sited sulfide and azide units were obtained in moderate to good yields with good tolerance of functional groups. The protocol uses readily available 1-(alkylthio)pyrrolidine-2,5-diones and trimethylsilyl azide as the alkylthiation and azidation reagents, respectively, inexpensive and environmentally friendly iron chloride as the catalyst without addition of any ligand and additive.

引用

页码：2806 / 2810

页数：5

共 73 条

[1] Palladium-catalyzed ring-forming aminoacetoxylation of alkenes [J].