Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage

被引:42
作者
Chen, Junfan [1 ]
Zheng, Zhiyuan Vera [1 ,2 ]
Lu, Gang [3 ,4 ]
Chan, Wai Yee [3 ]
Zhang, Yisen [5 ]
Wong, George Kwok Chu [1 ]
机构
[1] Chinese Univ Hong Kong, Div Neurosurg, Dept Surg, Hong Kong, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Dept Neurosurg, Sanya, Hainan, Peoples R China
[3] Chinese Univ Hong Kong, Sch Biomed Sci, CUHK SDU Joint Lab Reprod Genet, Hong Kong, Peoples R China
[4] Hong Kong Sci & Technol Pk, SDIVF R&D Ctr, Bioinformat Unit, Hong Kong, Peoples R China
[5] Capital Med Univ, Beijing Tiantan Hosp, Dept Intervent Neuroradiol, Beijing Neurosurg Inst, Beijing, Peoples R China
关键词
activation; inflammation; microglia; modulator; neuroinflammation; sequencing; signal pathway; single-cell analysis; stroke; subarachnoid hemorrhage; treatment; EARLY BRAIN-INJURY; DELAYED CEREBRAL-ISCHEMIA; ANALYSIS REVEALS; ADULT MICROGLIA; MYELOID CELLS; GALECTIN-3; POLARIZATION; STROKE; HMGB1; HETEROGENEITY;
D O I
10.4103/1673-5374.330589
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Subarachnoid hemorrhage is a devastating disease with significant mortality and morbidity, despite advances in treating cerebral aneurysms. There has been recent progress in the intensive care management and monitoring of patients with subarachnoid hemorrhage, but the results remain unsatisfactory. Microglia, the resident immune cells of the brain, are increasingly recognized as playing a significant role in neurological diseases, including subarachnoid hemorrhage. In early brain injury following subarachnoid hemorrhage, microglial activation and neuroinflammation have been implicated in the development of disease complications and recovery. To understand the disease processes following subarachnoid hemorrhage, it is important to focus on the modulators of microglial activation and the pro-inflammatory/anti-inflammatory cytokines and chemokines. In this review, we summarize research on the modulators of microglia-mediated inflammation in subarachnoid hemorrhage, including transcriptome changes and the neuroinflammatory signaling pathways. We also describe the latest developments in single-cell transcriptomics for microglia and summarize advances that have been made in the transcriptome-based classification of microglia and the implications for microglial activation and neuroinflammation.
引用
收藏
页码:1404 / 1411
页数:8
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