The pathway to secondary prevention of Alzheimer's disease

被引：7

作者：

McDade, Eric ^{[1
]}

Bednar, Martin M. ^{[2
]}

Brashear, H. Robert ^{[3
]}

Miller, David S. ^{[4
]}

Maruff, Paul ^{[5
]}

Randolph, Christopher ^{[6
,7
]}

Ismail, Zahinoor ^{[8
]}

Carrillo, Maria C. ^{[9
]}

Weber, Christopher J. ^{[9
]}

Bain, Lisa J.

Hake, Ann Marie ^{[10
,11
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Americas Inc, Takeda Pharmaceut Int Co, Cambridge, MA USA

[3] Janssen Res & Dev, San Francisco, CA USA

[4] Signant Hlth, Blue Bell, PA USA

[5] Cogstate Ltd, Melbourne, Vic, Australia

[6] MedAvante ProPhase, Hamilton, NJ USA

[7] Loyola Univ Med Ctr, Dept Neurol, Maywood, IL 60153 USA

[8] Univ Calgary, Cumming Sch Med, Calgary, AB, Canada

[9] Alzheimers Assoc, Chicago, IL USA

[10] Eli Lilly & Co, Indianapolis, IN 46285 USA

[11] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2020年 / 6卷 / 01期

关键词：

clinical trials; Alzheimer's disease; biomarkers; research roundtable;

D O I：

10.1002/trc2.12069

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a continuum consisting of a preclinical stage that occurs decades before symptoms appear. As researchers make advances in investigating the continuum, the importance of developing drugs for secondary prevention is garnering increased discussion. For efficacious drug development for secondary prevention it is important to define what are the earliest biological stages of AD. The Alzheimer's Association Research Roundtable convened November 27 to 28, 2018 to focus on preclinical AD. This review will address the biological approach to defining pre-clinical AD, detection, identification of at-risk individuals, and lessons learned from trials such as A4 and TOMMORROW.

引用

页数：9

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