Tubulin Post-Translational Modifications and Microtubule Dynamics

被引：114

作者：

Wloga, Dorota ^{[1
]}

Joachimiak, Ewa ^{[1
]}

Fabczak, Hanna ^{[1
]}

机构：

[1] Polish Acad Sci, Dept Cell Biol, Lab Cytoskeleton & Cilia Biol, Nencki Inst Expt Biol, 3 Pasteur Str, PL-02093 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 10期

关键词：

microtubule dynamics; post-translational modifications; acetylation; glutamylation; glycylation; methylation; phosphorylation; polyamination; DETYROSINATED ALPHA-TUBULINS; HUMAN BREAST CELLS; BETA-TUBULIN; TYROSINE LIGASE; CAENORHABDITIS-ELEGANS; STRUCTURAL BASIS; IN-VIVO; HDAC6-MEDIATED DEACETYLATION; AXONEMAL MICROTUBULES; AXONAL MICROTUBULES;

D O I：

10.3390/ijms18102207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microtubules are hollow tube-like polymeric structures composed of alpha,beta-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.

引用

页数：18

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