Association of BMI With Benefit of Metformin Plus Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Patients With Advanced Lung Adenocarcinoma A Secondary Analysis of a Phase 2 Randomized Clinical Trial

被引：18

作者：

Arrieta, Oscar ^{[1
]}

Zatarain-Barron, Zyanya Lucia ^{[1
]}

Turcott, Jenny G. ^{[1
]}

Barron, Feliciano ^{[1
]}

Yendamuri, Sai ^{[2
]}

Cardona, Andres F. ^{[3
,4
,5
]}

Rosell, Rafael ^{[6
,7
]}

机构：

[1] Inst Nacl Cancerol, Thorac Oncol Unit, Av San Fernando 22,Secc XVI, Mexico City 14080, DF, Mexico

[2] Roswell Park Comprehens Canc Ctr, Dept Thorac Surg, Buffalo, NY USA

[3] Luis Carolos Sarmiento Angulo Canc Treatment & Re, Bogota, Colombia

[4] Fdn Clin & Appl Canc Res, Bogota, Colombia

[5] Univ El Bosque, Mol Oncol & Biol Syst Res Grp, Bogota, Colombia

[6] Germans Trias & Pujol Res Inst, Catalan Inst Oncol, Barcelona, Spain

[7] Hosp Campus Can Ruti, Barcelona, Spain

来源：

JAMA ONCOLOGY | 2022年 / 8卷 / 03期

关键词：

D O I：

10.1001/jamaoncol.2021.7015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This secondary analysis reports the survival outcome in patients with EGFR variant-positive non-small-cell lung cancer who had a body mass index that was higher or lower than 24.

引用

页码：477 / 479

页数：3

共 6 条

[1] Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma A Phase 2 Randomized Clinical Trial [J].

Arrieta, Oscar ;

Barron, Feliciano ;

Salinas Padilla, Miguel-Angel ;

Aviles-Salas, Alejandro ;

Alejandra Ramirez-Tirado, Laura ;

Arguelles Jimenez, Manuel Jesus ;

Vergara, Edgar ;

Lucia Zatarain-Barron, Zyanya ;

Hernandez-Pedro, Norma ;

Cardona, Andres F. ;

Cruz-Rico, Graciela ;

Barrios-Bernal, Pedro ;

Yamamoto Ramos, Masao ;

Rosell, Rafael .

JAMA ONCOLOGY, 2019, 5 (11)

[2] Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer [J].

Arrieta, Oscar ;

Varela-Santoyo, Edgar ;

Soto-Perez-de-Celis, Enrique ;

Sanchez-Reyes, Roberto ;

De la Torre-Vallejo, Martha ;

Muniz-Hernandez, Sae ;

Cardona, Andres F. .

BMC CANCER, 2016, 16

[3]

Arrieta O, 2013, REV INVEST CLIN, V65, pS5

[4] Combination of Metformin and Gefitinib as First-Line Therapy for Nondiabetic Advanced NSCLC Patients with EGFR Mutations: A Randomized, Double-Blind Phase II Trial [J].

Li, Li ;

Jiang, Liyan ;

Wang, Yubo ;

Zhao, Yizhuo ;

Zhang, Xiao-Ju ;

Wu, Guoming ;

Zhou, Xiangdong ;

Sun, Jianguo ;

Bai, Jun ;

Ren, Biyong ;

Tian, Kun ;

Xu, Zhi ;

Xiao, Hua-liang ;

Zhou, Qi ;

Han, Rui ;

Chen, Hengyi ;

Wang, Haidong ;

Yang, Zhenzhou ;

Gao, Chan ;

Cai, Shangli ;

He, Yong .

CLINICAL CANCER RESEARCH, 2019, 25 (23) :6967-6975

[5]

Ritchie H., 1995, Obesity"

[6] Body Mass Index Influences the Salutary Effects of Metformin on Survival After Lobectomy for Stage I NSCLC [J].

Yendamuri, Sai ;

Barbi, Joseph ;

Pabla, Sarabjot ;

Petrucci, Cara ;

Punnanitinont, Achamaporn ;

Nesline, Mary ;

Glenn, Sean T. ;

Depietro, Paul ;

Papanicalou-Sengos, Antonios ;

Morrison, Carl ;

Dy, Grace K. ;

Elkin, Peter L. .

JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (12) :2181-2187

← 1 →