MicroRNA Profiling in Asthma: Potential Biomarkers and Therapeutic Targets

被引：53

作者：

Heffler, Enrico ^{[1
,2
]}

Allegra, Alessandro ^{[3
]}

Pioggia, Giovanni ^{[4
]}

Picardi, Giuseppe ^{[6
]}

Musolino, Caterina ^{[3
]}

Gangemi, Sebastiano ^{[4
,5
]}

机构：

[1] Humanitas Univ, Humanitas Res Hosp, Personalized Med Asthma & Allergy Clin, Milan, Italy

[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[3] Univ Messina, Dept Gen Surg & Oncol, Div Hematol, Messina, Italy

[4] Univ Hosp G Martino, Messina Unit, Inst Appl Sci & Intelligent Syst, Messina, Italy

[5] Univ Hosp G Martino, Dept Clin & Expt Med, Sch & Div Allergy & Clin Immunol, Messina, Italy

[6] Univ Catania, Dept Clin & Expt Med, Resp Dis & Allergy, Catania, Italy

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2017年 / 57卷 / 06期

关键词：

asthma; biomarkers; cytokine; exosome; miRNA; AIRWAY SMOOTH-MUSCLE; BRONCHIAL EPITHELIAL-CELLS; MESENCHYMAL TRANSITION; CIRCULATING MICRORNAS; ALLERGIC RHINITIS; GABA(A) RECEPTORS; T-CELLS; EXPRESSION; DIFFERENTIATION; ACTIVATION;

D O I：

10.1165/rcmb.2016-0231TR

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. MicroRNAs (miRNAs) are a group of minute, endogenous 22-25 nt RNA elements that join to particular mRNAs to reduce translation and increase messenger RNA degradation. miRNAs operate in post-transcriptional control and regulate physiological and pathological processes in several illnesses. The purpose of this work is to review and discuss the current knowledge about the function of miRNAs in asthma, focusing particularly on their biological properties, pathophysiologic actions, and possible use as markers and treatments for asthma.

引用

页码：642 / 650

页数：9

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