Genomic and Metabolomic Landscape of Right-Sided and Left-Sided Colorectal Cancer: Potential Preventive Biomarkers

被引：10

作者：

Su, Ming-Wei ^{[1
]}

Chang, Chung-Ke ^{[1
]}

Lin, Chien-Wei ^{[1
]}

Chu, Hou-Wei ^{[1
]}

Tsai, Tsen-Ni ^{[2
]}

Su, Wei-Chih ^{[2
,3
]}

Chen, Yen-Cheng ^{[2
,3
]}

Chang, Tsung-Kun ^{[2
]}

Huang, Ching-Wen ^{[2
,4
]}

Tsai, Hsiang-Lin ^{[2
,4
]}

Wu, Chang-Chieh ^{[5
]}

Chou, Huang-Chi ^{[6
,7
]}

Shiu, Bei-Hao ^{[6
,7
]}

Wang, Jaw-Yuan ^{[2
,3
,4
,8
,9
,10
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Colorectal Surg, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807, Taiwan

[4] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Surg, Kaohsiung 807, Taiwan

[5] Triserv Gen Hosp, Dept Surg, Keelung Branch, Natl Def Med Ctr, Keelung 20042, Taiwan

[6] Chung Shan Med Univ, Sch Med, Taichung 402306, Taiwan

[7] Chung Shan Med Univ Hosp, Dept Surg, Div Colon & Rectal Surg, Taichung 402306, Taiwan

[8] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung 807, Taiwan

[9] Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res, Kaohsiung 807, Taiwan

[10] Pingtung Hosp, Minist Hlth & Welf, Pingtung 900, Taiwan

来源：

CELLS | 2022年 / 11卷 / 03期

关键词：

colorectal cancer; whole exome sequence; polygenic risk score; metabolomic profiling; SURVIVAL; CHINESE;

D O I：

10.3390/cells11030527

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Colorectal cancer (CRC) is the third most common cancer worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than in other developed countries. Genes involved in CRC tumorigenesis differ depending on whether the tumor occurs on the left or right side of the colon, and genomic analysis is a keystone in the study and treatment of CRC subtypes. However, few studies have focused on the genetic landscape of Taiwanese patients with CRC. This study comprehensively analyzed the genomes of 141 Taiwanese patients with CRC through whole-exome sequencing. Significant genomic differences related to the site of CRC development were observed. Blood metabolomic profiling and polygenic risk score analysis were performed to identify potential biomarkers for the early identification and prevention of CRC in the Taiwanese population. Our findings provide vital clues for establishing population-specific treatments and health policies for CRC prevention in Taiwan.

引用

页数：12

共 40 条

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