Single-dose antibiotic prophylaxis for urinary catheter removal does not reduce the risk of urinary tract infection in surgical patients: a randomized double-blind placebo-controlled trial

被引：13
|
作者：
van Hees, B. C. [1 ]
Vijverberg, P. L. M. [2 ]
Hoorntje, L. E. [3 ]
Wiltink, E. H. H. [4 ]
Go, P. M. N. Y. H. [3 ]
Tersmette, M. [1 ]
机构：
[1] St Antonius Hosp, Dept Med Microbiol & Immunol, Nieuwegein, Netherlands
[2] St Antonius Hosp, Dept Urol, Nieuwegein, Netherlands
[3] St Antonius Hosp, Dept Surg, Nieuwegein, Netherlands
[4] St Antonius Hosp, Dept Clin Pharm, Nieuwegein, Netherlands
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2011年 / 17卷 / 07期
关键词：
Antibiotic prophylaxis; catheter removal; urinary catheter; ASYMPTOMATIC BACTERIURIA; NO THERAPY; WOMEN;
D O I：
10.1111/j.1469-0691.2010.03447.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We conducted a double-blind, placebo-controlled randomized trial to assess the effect of single-dose prophylaxis using co-trimoxazole (960 mg) (n = 46) or ciprofloxacin (500 mg) (n = 43) vs. placebo (n = 51) before urinary catheter removal on significant bacteriuria (SBU) (primary outcome) and urinary tract infection (UTI) in surgical patients with scheduled bladder drainage for 314 days. SBU was determined directly after catheter removal, and UTI 12-14 days after catheter removal. After 12-14 days, incidences of SBU were 19%, 19% and 33% for patients receiving ciprofloxacin, co-trimoxazole and placebo, respectively (p ns), and incidences of UTI were 3%, 0% and 3% for patients receiving ciprofloxacin, co-trimoxazole and placebo, respectively (p ns).
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页码：1091 / 1094
页数：4
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