Update on the etiopathogenesis of psoriasis (Review)

被引:48
作者
Branisteanu, Daciana Elena [1 ]
Cojocaru, Catalina [2 ]
Diaconu, Roxana [2 ]
Porumb-Andrese, Elena [3 ]
Alexa, Anisia Iuliana [4 ]
Nicolescu, Alin Codrut [5 ]
Brihan, Ilarie [6 ]
Bogdanici, Camelia Margareta [4 ]
Branisteanu, George [7 ]
Dimitriu, Andreea [8 ]
Zemba, Mihail [9 ]
Anton, Nicoleta [4 ]
Toader, Mihaela Paula [10 ]
Grechin, Adrian [11 ]
Branisteanu, Daniel Constantin [4 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Dept Dermatol, Iasi 2700115, Romania
[2] Railway Clin Hosp, Dept Dermatol, 1 Garabet Ibraileanu St, Iasi 700506, Romania
[3] Sf Spiridon Clin Emergency Cty Hosp, Dept Dermatol, Iasi 700111, Romania
[4] Grigore T Popa Univ Med & Pharm, Dept Ophthalmol, Iasi 700115, Romania
[5] Roma Med Ctr Diag & Treatment, Dept Dermatol, Bucharest 011773, Romania
[6] Univ Oradea, Fac Med & Pharm, Dept Dermatol, Dermatol Clin, Oradea 410073, Romania
[7] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania
[8] Arcadia Hosp & Med Ctr, Dept Dermatol, Iasi 700620, Romania
[9] Carol Davila Univ Med & Pharm, Dept Ophthalmol, 37 Dionisie Lupu St,Dist 2, Bucharest 020021, Romania
[10] Grigore T Popa Univ Med & Pharm, Dept Oral Dermatol, Iasi 700115, Romania
[11] Sf Spiridon Clin Emergency Cty Hosp, Dept Ophthalmol, Iasi 700111, Romania
关键词
psoriasis; etiopathogenesis; immunity; lymphocytes; cytokines; tissue resident memory cells; biologic therapies; MEMORY T-CELLS; INFLAMMATORY-BOWEL-DISEASE; DENDRITIC CELLS; INTERFERON-GAMMA; LESIONAL SKIN; GENOME-WIDE; TH17; CELLS; PHASE-III; ANTIMICROBIAL PEPTIDES; EPIDERMAL HYPERPLASIA;
D O I
10.3892/etm.2022.11124
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders, involving hyperproliferative keratinocytes and infiltration of T cells, dendritic cells, macrophages, and neutrophils. Multiple factors appear to play important roles in the pathogenesis of psoriasis. These environmental (e.g., infectious agents and trauma), genetic, and immunologic factors are reviewed in this article. Although the pathogenesis of psoriasis remains to be established, data suggesting immune cell dysregulation in the skin are available. The involvement of the immune system, particularly T cells, in the etiopathogenesis of psoriasis is discussed in this review, indicating a potential justification for innovative treatment intervention. Besides describing pathogenic T cells, the aim of the review was to assess the function of newly identified antimicrobial peptides (AMPs), interleukin (IL)-23, IL-17, and tissue resident memory cells (TRMs), and their role in psoriasis. Furthermore, new insights were presented regarding TRMs, a recently identified subset of memory T cells, and the role they play in the local memory of disease, making them a potential new therapeutic target in psoriasis. Finally, current developments in T-cell research and cytokine-targeted therapy for psoriasis treatment are reviewed.
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页数:13
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