PI-PLCβ-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes

被引：34
作者：
Follo, M. Y. [1 ]
Finelli, C. [2 ]
Bosi, C. [2 ,3 ]
Martinelli, G. [2 ]
Mongiorgi, S. [1 ]
Baccarani, M. [2 ]
Manzoli, L. [1 ]
Blalock, W. L. [1 ]
Martelli, A. M. [1 ,4 ]
Cocco, L. [1 ]
机构：
[1] Univ Bologna, Dept Analyt Sci, Cellular Signalling Lab, Bologna, Italy
[2] Univ Bologna, Inst Hematol & Med Oncol, Bologna, Italy
[3] Ospedale Civile Piacenza, Hematol Unit, Piacenza, Italy
[4] IOR, Sez Bologna, Ist Trapianti Organo & Immunocitol CNR, Bologna, Italy
来源：
LEUKEMIA | 2008年 / 22卷 / 01期
关键词：
D O I：
10.1038/sj.leu.2404855
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：198 / 200
页数：4
相关论文
共 8 条
  • [1] Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia
    Cheson, Bruce D.
    Greenberg, Peter L.
    Bennett, John M.
    Lowenberg, Bob
    Wijermans, Pierre W.
    Nimer, Stephen D.
    Pinto, Antonio
    Beran, Miloslav
    de Witte, Theo M.
    Stone, Richard M.
    Mittelman, Moshe
    Sanz, Guillermo F.
    Gore, Steven D.
    Schiffer, Charles A.
    Kantarjian, Hagop
    [J]. BLOOD, 2006, 108 (02) : 419 - 425
  • [2] Signal transduction within the nucleus:: Revisiting phosphoinositide inositide-specific phospholipase Cβ1
    Cocco, Lucio
    Martelli, Alberto M.
    Fiume, Roberta
    Faenza, Irene
    Billi, Anna Maria
    Manzoli, Francesco Antonio
    [J]. ADVANCES IN ENZYME REGULATION, VOL 46, PROCEEDINGS, 2006, 46 : 2 - 11
  • [3] Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
    Daskalakis, M
    Nguyen, TT
    Nguyen, C
    Guldberg, P
    Köhler, G
    Wijermans, P
    Jones, PA
    Lübbert, M
    [J]. BLOOD, 2002, 100 (08) : 2957 - 2964
  • [4] The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
    Follo, Matilde Y.
    Mongiorgi, Sara
    Bosi, Costanza
    Cappenini, Alessandra
    Finelli, Carlo
    Chiarini, Francesca
    Papa, Veronica
    Libra, Massimo
    Martinelli, Giovanni
    Cocco, Lucio
    Martelli, Alberto M.
    [J]. CANCER RESEARCH, 2007, 67 (09) : 4287 - 4294
  • [5] Follo MY, 2006, INT J MOL MED, V18, P267
  • [6] Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
    Kaminskas, E
    Farrell, A
    Abraham, S
    Baird, A
    Hsieh, LS
    Lee, SL
    Leighton, JK
    Patel, H
    Rahman, A
    Sridhara, R
    Wang, YC
    Pazdur, R
    [J]. CLINICAL CANCER RESEARCH, 2005, 11 (10) : 3604 - 3608
  • [7] Inositide-specific phospholipase c β1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia
    Lo Vasco, VR
    Calabrese, G
    Manzoli, L
    Palka, G
    Spadano, A
    Morizio, E
    Guanciali-Franchi, P
    Fantasia, D
    Cocco, L
    [J]. LEUKEMIA, 2004, 18 (06) : 1122 - 1126
  • [8] Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    Silverman, LR
    Demakos, EP
    Peterson, BL
    Kornblith, AB
    Holland, JC
    Odchimar-Reissig, R
    Stone, RM
    Nelson, D
    Powell, BL
    DeCastro, CM
    Ellerton, J
    Larson, RA
    Schiffer, CA
    Holland, JF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (10) : 2429 - 2440
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