Global analysis of mRNA splicing

被引：58

作者：

Moore, Michael J. ^{[1
]}

Silver, Pamela A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

RNA | 2008年 / 14卷 / 02期

关键词：

mRNA splicing; systems biology; genome-wide; alternative splicing regulation; microarrays; RNA network;

D O I：

10.1261/rna.868008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative mRNA splicing is a rich source of transcript diversity in eukaryotic cells with broad roles in development and disease. Systems-wide experimental methods have started to define how global splicing regulation shapes complex biological properties and pathways. Here, we review these approaches, describe recent insights they have yielded, and discuss avenues of future investigation.

引用

页码：197 / 203

页数：7

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