Pharmacogenomics Implementation at the National Institutes of Health Clinical Center

被引：17

作者：

Sissung, Tristan M. ^{[1
]}

McKeeby, Jon W. ^{[2
]}

Patel, Jharana ^{[3
]}

Lertora, Juan J. ^{[4
]}

Kumar, Parag ^{[5
]}

Flegel, Willy A. ^{[6
]}

Adams, Sharon D. ^{[6
]}

Eckes, Ellen J. ^{[7
]}

Mickey, Frank ^{[2
]}

Plona, Teri M. ^{[8
,9
]}

Mellot, Stephanie D. ^{[8
,9
]}

Baugher, Ryan N. ^{[8
,9
]}

Wu, Xiaolin ^{[9
,10
]}

Soppet, Daniel R. ^{[9
,10
]}

Barcus, Mary E. ^{[8
,9
]}

Datta, Vivekananda ^{[8
,9
,11
]}

Pike, Kristen M. ^{[8
,9
]}

DiPatrizio, Gary ^{[2
]}

Figg, William D. ^{[1
]}

Goldspiel, Barry R. ^{[3
]}

机构：

[1] NCI, Clin Pharmacol Program, Off Clin Director, Rockville, MD USA

[2] NIH, Dept Clin Res Informat, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[3] NIH, Dept Pharm, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[4] NIH, Clin Pharmacol Program, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[5] NIH, Clin Pharmacokinet Res Lab, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA

[6] NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA

[7] NIH, Med Surg Specialties Serv, Ctr Clin, Dept Nursing, Bldg 10, Bethesda, MD 20892 USA

[8] Leidos Biomed Res Inc, CLIA Mol Diagnost Lab, Canc Res Technol Program, Frederick, MD USA

[9] Leidos Biomed Res Inc, Mol Characterizat Lab, Frederick Natl Lab Canc Res, Frederick, MD USA

[10] Leidos Biomed Res Inc, Genom Lab, Res Technol Program, Frederick, MD USA

[11] Leidos Biomed Res Inc, Mol Characterizat Lab, Canc Res Technol Program, Frederick, MD USA

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 2017年 / 57卷 / 10期

关键词：

pharmacogenomics; implementation; precision medicine; translation; PRECISION MEDICINE; DECISION-SUPPORT; INFORMATION; GUIDELINES; CONSORTIUM; PROGRAMS;

D O I：

10.1002/jcph.993

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The National Institutes of Health Clinical Center (NIH CC) is the largest hospital in the United States devoted entirely to clinical research, with a highly diverse spectrum of patients. Patient safety and clinical quality are major goals of the hospital, and therapy is often complicated by multiple cotherapies and comorbidities. To this end, we implemented a pharmacogenomics program in 2 phases. In the first phase, we implemented genotyping for HLA-A and HLA-B gene variations with clinical decision support (CDS) for abacavir, carbamazepine, and allopurinol. In the second phase, we implemented genotyping for drug-metabolizing enzymes and transporters: SLCO1B1 for CDS of simvastatin and TPMT for CDS of mercaptopurine, azathioprine, and thioguanine. The purpose of this review is to describe the implementation process, which involves clinical, laboratory, informatics, and policy decisions pertinent to the NIH CC.

引用

页码：S67 / S77

页数：11

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