Encoded fiber-optic microsphere arrays for probing protein-carbohydrate interactions

被引：44

作者：

Adams, EW

Ueberfeld, J

Ratner, DM

O'Keefe, BR

Walt, DR ^{[1
]}

Seeberger, PH

机构：

[1] Tufts Univ, Dept Chem, Max Tishler Lab Organ Chem, Medford, MA 02155 USA

[2] NCI, Mol Targets Dev Program, NCI Ctr Canc Res, Ft Detrick, MD 21702 USA

[3] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 43期

关键词：

biosensors; carbohydrates; proteins;

D O I：

10.1002/anie.200351286

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Protein-carbohydrate interactions can be evaluated by using randomly ordered fiber optic microsphere arrays bearing immobilized synthetic oligosaccharides (see scheme). Two systems are examined: the mannose-binding lectin concanavalin A, and cyanovirin N. The latter allows the simultaneous evaluation of five distinct structure against a carbohydrate-binding protein with unambiguous results.

引用

页码：5317 / 5320

页数：4

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SCIENCE, 2001, 291 (5512) :2370-2376

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