Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function

被引：5

作者：

Darton, Tom C. ^{[1
,2
]}

Wing, James B. ^{[1
]}

Lees, Andrew ^{[3
]}

Heath, Andrew W. ^{[1
]}

Read, Robert C. ^{[1
,2
]}

机构：

[1] Univ Sheffield, Sch Med, Dept Infect & Immun, Sheffield S10 2RX, S Yorkshire, England

[2] Sheffield Teaching Hosp NHS Fdn Trust, Royal Hallamshire Hosp, Dept Infect & Trop Med, Sheffield, S Yorkshire, England

[3] Fina Biosolut, Rockville, MD USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 52卷 / 09期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

CONJUGATE VACCINE; POLYSACCHARIDE; IMMUNODEFICIENCY;

D O I：

10.1093/cid/cir126

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to alpha delta-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.

引用

页码：1133 / 1136

页数：4

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