Soluble fms-like tyrosine kinase 1 and placental growth factor ratio for predicting preeclampsia in elderly gravida

被引：8

作者：

Phupong, Vorapong ^{[1
]}

Areeruk, Wilasinee ^{[1
]}

Tantbirojn, Patau ^{[1
]}

Lertkhachonsuk, Ruangsak ^{[1
]}

机构：

[1] Chulalongkorn Univ, Fac Med, Dept Obstet & Gynecol, Bangkok, Thailand

来源：

HYPERTENSION IN PREGNANCY | 2020年 / 39卷 / 02期

关键词：

Preeclampsia; soluble fms-like tyrosine kinase 1; placental growth factor; ratio; elderly gravida; UTERINE ARTERY DOPPLER; RISK-FACTORS; ANGIOGENIC BIOMARKERS; EARLY-ONSET; COMBINATION; GESTATION;

D O I：

10.1080/10641955.2020.1745227

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To determine the predictive value of plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) ratio for detection of preeclampsia in elderly gravida at 16-18 weeks of gestation and to identify whether abnormalities of this ratio are associated with any other pregnancy complications or not. Methods: Blood samples of 300 cases were collected. Plasma sFlt-1 and PlGF levels were measured using an automated immunoassay. Results: Sensitivity and specificity for plasma sFlt-1/PlGF ratio above 9.8 for preeclampsia prediction were 85.7% and 61.2%, respectively. The sensitivity and specificity to predict early onset preeclampsia were 100% and 61.1%, respectively. Women with abnormal plasma sFlt-1/PlGF ratio were not associated with any other pregnancy complications. Conclusion: sFlt-1/PlGF ratio at 16-18 weeks of gestation in elderly gravida has a high sensitivity for predicting preeclampsia, especially early onset preeclampsia.

引用

页码：139 / 144

页数：6

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