Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats

被引:18
作者
da Rocha, Juliana Trevisan
Pinton, Simone
Mazzanti, Alexandre [2 ]
Mazzanti, Cinthia Melazzo [2 ]
Beckemann, Diego Vilibaldo [2 ]
Nogueira, Cristina Wayne
Zeni, Gilson [1 ]
机构
[1] Univ Fed Santa Maria, Dept Quim, Ctr Ciencias Nat & Exatas, Lab Sintese Reatividade & Avaliacao Farmacol & To, BR-97105900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Lab Cirurgia Expt DCPA, Ctr Ciencias Rurais, BR-97105900 Santa Maria, RS, Brazil
关键词
cholesterol; menopause; ovariectomy; oxidative stress; selenium; HORMONE REPLACEMENT THERAPY; ANTIDEPRESSANT-LIKE; PLASMA; LIVER; GLUTATHIONE; SELENIUM; DAMAGE; ACID; MICE; POSTMENOPAUSAL;
D O I
10.1111/j.2042-7158.2011.01255.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objectives Ovarian hormone decline after menopause is linked to many pathophysiological reactions. Female rats submitted to ovariectomy are employed as a model of post-menopausal condition. This study investigated the effects of diphenyl diselenide (PhSe)(2) on body weight gain, intra-abdominal fat deposition, plasma lipid profile and hepatic oxidative stress in ovariectomized rats. Methods Female adult Wistar rats were ovariectomized (OVX rats) or sham-operated and divided into four groups: (i) sham-operated, (ii) (PhSe)(2), (iii) OVX and (iv) OVX + (PhSe)(2). (PhSe)(2) (5 mg/kg; 5 ml/kg, p.o.) was administered once a day for 30 days to groups (ii) and (iv). After that, rats were anaesthetized for blood sample gathering and submitted to euthanasia. Key findings (PhSe)(2) (5 mg/kg) was effective in preventing the rise in body weight gain and intra-abdominal fat deposition induced in OVX rats. Although (PhSe)(2) was not effective in avoiding the increase in plasma total cholesterol and non-HDL levels induced in OVX rats, (PhSe)(2) reduced plasma triglycerides and augmented HDL levels in OVX rats. (PhSe)(2) also increased hepatic ascorbic acid levels, reduced glutathione content, glutathione S-transferase activity and restored catalase activity in liver of OVX rats. Conclusions These findings suggest that (PhSe)(2) could be a promising alternative to minimize menopause related symptoms.
引用
收藏
页码:663 / 669
页数:7
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