Stevens-Johnson syndrome induced by acetazolamide

被引：26

作者：

Her, Young ^{[1
]}

Kil, Min S. ^{[1
]}

Park, Ju H. ^{[1
]}

Kim, Chul W. ^{[1
]}

Kim, Sang S. ^{[1
]}

机构：

[1] Hallym Univ, Dept Dermatol, Coll Med, Seoul, South Korea

来源：

JOURNAL OF DERMATOLOGY | 2011年 / 38卷 / 03期

关键词：

acetazolamide; HLA-B59; Stevens-Johnson syndrome toxic epidermal necrolysis; METHAZOLAMIDE TREATMENT;

D O I：

10.1111/j.1346-8138.2010.00921.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Acetazolamide is a sulfonamide derivative and carbonic anhydrase inhibitor used to lower intraocular pressure in glaucomatous patients. Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) associated with acetazolamide treatment has been diagnosed in Japanese, Japanese-American and Indian patients. Herein, we report the second Korean case of SJS-TEN associated with acetazolamide treatment. The result of human leukocyte antigen (HLA) typing of our patient was positive for HLA-B59. According to recent research, HLA-B59 has been detected in SJS caused by metazolamide, which is analogous to acetazolamide. This suggests a possible relationship between genetic background and SJS-TEN-associated acetazolamide treatment. Theretofore, acetazolamide should be prescribed to Korean patients with the same discreet caution.

引用

页码：272 / 275

页数：4

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