Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine

被引:7
作者
Urban, A [1 ]
Libiger, J
Hosák, L
Kupka, K
机构
[1] Univ Hosp, Dept Psychiat, Hradec Kralove 50005, Czech Republic
[2] Charles Univ, Sch Med 1, Inst Nucl Med, Prague, Czech Republic
关键词
schizophrenia; parkinsonism; clozapine; SPECT;
D O I
10.1016/S0924-9338(03)00068-3
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS). We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS. Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain. A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way. This helped us to find a proper therapeutic strategy for our patient. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:258 / 259
页数:2
相关论文
共 6 条
[1]   Extrapyramidal symptoms during long-term treatment with antipsychotics - Special focus on clozapine and D-1 and D-2 dopamine antagonists [J].
Gerlach, J ;
Lublin, H ;
Peacock, L .
NEUROPSYCHOPHARMACOLOGY, 1996, 14 (03) :S35-S39
[2]   Decreased striatal dopamine transporter binding in vivo in chronic schizophrenia [J].
Laakso, A ;
Bergman, J ;
Haaparanta, M ;
Vilkman, H ;
Solin, O ;
Syvälahti, E ;
Hietala, J .
SCHIZOPHRENIA RESEARCH, 2001, 52 (1-2) :115-120
[3]   Dopamine and serotonin transporters in patients with schizophrenia:: An imaging study with [123I]β-CIT [J].
Laruelle, M ;
Abi-Dargham, A ;
van Dyck, C ;
Gil, R ;
D'Souza, DC ;
Krystal, J ;
Seibyl, J ;
Baldwin, R ;
Innis, R .
BIOLOGICAL PSYCHIATRY, 2000, 47 (05) :371-379
[4]   Dopamine transporter density in young patients with schizophrenia assessed with [123] FP-CIT SPECT [J].
Lavalaye, J ;
Linszen, DH ;
Booij, J ;
Dingemans, PMAJ ;
Reneman, L ;
Habraken, BAJ ;
Gersons, BPR ;
van Royen, EA .
SCHIZOPHRENIA RESEARCH, 2001, 47 (01) :59-67
[5]   Reduced striatal dopaminergic innervation shown by IPT and SPECT in patients under neuroleptic treatment: need for levodopa therapy? [J].
Schwarz, J ;
Scherer, J ;
Trenkwalder, C ;
Mozley, PD ;
Tatsch, K .
PSYCHIATRY RESEARCH-NEUROIMAGING, 1998, 83 (01) :23-28
[6]   Clozapine treatment for neuroleptic-induced tardive dyskinesia, parkinsonism, and chronic akathisia in schizophrenic patients [J].
Spivak, B ;
Mester, R ;
Abesgaus, J ;
Wittenberg, N ;
Adlersberg, S ;
Gonen, N ;
Weizman, A .
JOURNAL OF CLINICAL PSYCHIATRY, 1997, 58 (07) :318-322