Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty

被引：12

作者：

Ozsarlak-Sozer, Gonen ^{[1
]}

Kerry, Zeliha ^{[1
]}

Gokce, Goksel ^{[1
]}

Oran, Ismail ^{[2
]}

Topcu, Zeki ^{[3
]}

机构：

[1] Ege Univ, Dept Pharmacol, TR-35100 Izmir, Turkey

[2] Ege Univ, Dept Radiol, Fac Med, TR-35100 Izmir, Turkey

[3] Ege Univ, Dept Pharmaceut Biotechnol, Fac Pharm, TR-35100 Izmir, Turkey

来源：

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY | 2011年 / 67卷 / 01期

关键词：

Oxidative stress; Telomere length; Balloon angioplasty; Atherosclerosis; GLUTATHIONE DEPLETION; MOLECULAR-MECHANISMS; CELLULAR SENESCENCE; ENDOTHELIAL-CELLS; HUMAN FIBROBLASTS; DNA; TAURINE; REPLICATION; ASSOCIATION; INDUCTION;

D O I：

10.1007/s13105-010-0046-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are specialized DNA-protein complexes found at the tips of linear chromosomes. In this study, we investigated the effects of oxidative stress on telomeric length distribution of proliferating vascular smooth muscle cells following balloon injury in single or combined treatment of rabbits with either buthionine sulfoximine or taurine. Exposure to oxidative stress increased the balloon injury whereas taurine treatment significantly diminished l-buthionine-sulfoximine-related intimal hyperplasia. Our results also showed that both variables had a significant influence on mean telomeric length distribution.

引用

页码：35 / 42

页数：8

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