Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats

被引：0

作者：

Sabo, I. J. R. ^{[1
]}

Lakic, Tanja Z. ^{[2
,3
]}

Capo, Ivan D. ^{[1
]}

Andrejic-Visnjic, Bojana M. ^{[1
]}

Matavulj, Milica ^{[4
]}

Djolai, Matilda A. ^{[1
,2
]}

机构：

[1] Univ Novi Sad, Fac Med, Dept Histol & Embryol, Hajduk Veljkova 3, Novi Sad, Serbia

[2] Ctr Pathol & Histol, Clin Ctr Vojvodina, Hajduk Veljkova 1-9, Novi Sad, Serbia

[3] Univ Novi Sad, Fac Med, Dept Pathol, Hajduk Veljkova 3, Novi Sad, Serbia

[4] Univ Novi Sad, Fac Sci, Dept Biol & Ecol, Trg Dositeja Obradovica 2, Novi Sad, Serbia

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2021年 / 39卷 / 04期

关键词：

Acrylamide; Food; Stomach; Wistar Rat; Toxicity;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric tissue in Wistar rats induced with injection of oral acrylamide. The research was carried out 6 groups of 5 animals (Wistar rats), two control groups and four experimental groups. Histological changes in the stomach tissue of Wistar rats are seen as a direct slight damage of the surface epithelium, accompanynig inflammatory reaction and renewal of the epithelium. Examined inflammatory and degenerative parameters show a positive correlation with respect to dose and time of exposition to acrylamide. Knowing the mechanism of action of these toxic substances, allows to apply adequate prevention in nutrition and make an appropriate choice of therapeutic methods.

引用

页码：963 / 968

页数：6

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