Genetics of Sjogren's syndrome

被引：43
作者：
Teos, Leyla Y. [1 ]
Alevizos, Ilias [1 ]
机构：
[1] Natl Inst Dent & Craniofacial Res, Sjogrens Syndrome & Salivary Gland Dysfunct Unit, NIH, Bethesda, MD USA
来源：
CLINICAL IMMUNOLOGY | 2017年 / 182卷
关键词：
HLA CLASS-II; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; REGULATORY FACTOR 5; RHEUMATOID-ARTHRITIS; PLATELET SEROTONIN; AUTOIMMUNE-DISEASES; JAPANESE PATIENTS; SICCA SYNDROME; TNF-ALPHA;
D O I：
10.1016/j.clim.2017.04.018
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The pathogenesis of Sjogren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases. Published by Elsevier Inc.
引用
收藏
页码：41 / 47
页数：7
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