Effects of an Alkaline Diet on EGFR-TKI Therapy in EGFR Mutation-positive NSCLC

被引：20

作者：

Hamaguchi, Reo ^{[1
]}

Okamoto, Toshihiro ^{[2
]}

Sato, Masaaki ^{[1
]}

Hasegawa, Michiko ^{[1
]}

Wada, Hiromi ^{[1
]}

机构：

[1] Karasuma Wada Clin, Yasaka Karasuma Oike Bldg 2F, Kyoto, Japan

[2] Cleveland Clin, Transplant Ctr, Cleveland, OH 44106 USA

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 09期

关键词：

Non-small cell lung cancer; EGFR mutation; low dose EGFR-TKI; alkaline diet; fruit and vegetables; pH regulation; urine pH; tumor microenvironment; Na+/H+ exchanger; CELL LUNG-CANCER; 1ST-LINE TREATMENT; PROTEOMIC ANALYSIS; OPEN-LABEL; URINE PH; GEFITINIB; ADENOCARCINOMA; CHEMOTHERAPY; METAANALYSIS; PACLITAXEL;

D O I：

10.21873/anticanres.11934

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The acidic tumor microenvironment is associated with progression of cancers. The purpose of this study was to investigate the association between an alkaline diet and the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in non-small cell lung cancer (NSCLC) patients. Patients and Methods: Eleven advanced or recurrent NSCLC patients with EGFR mutations treated with EGFR-TKI after being instructed to follow an alkaline diet were retrospectively evaluated. Results: The median progression-free survival (PFS) and overall survival (OS) were 19.5 (range= 3.1-33.8) and 28.5 (range= 15.4-46.6) months. The average dosage of EGFR-TKI was 56 +/- 22% of the standard dosage. Urine pH was significantly increased after the alkaline diet (6.00 +/- 0.38 vs. 6.95 +/- 0.55; p< 0.05). Conclusion: An alkaline diet may enhance the effect of EGFR-TKI treatment in NSCLC patients with EGFR mutations.

引用

页码：5141 / 5145

页数：5

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