PML bodies: a meeting place for genomic loci?

被引：112

作者：

Ching, RW ^{[1
]}

Dellaire, G ^{[1
]}

Eskiw, CH ^{[1
]}

Bazett-Jones, DP ^{[1
]}

机构：

[1] Hosp Sick Children, Cell Biol Programme, Res Inst, Toronto, ON M5G 1X8, Canada

来源：

JOURNAL OF CELL SCIENCE | 2005年 / 118卷 / 05期

关键词：

PML body; DNA replication; gene transcription; chromatin; viral gene expression;

D O I：

10.1242/jcs.01700

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Promyelocytic leukemia (PML) bodies have been implicated in a variety of cellular processes, such as cell-cycle regulation, apoptosis, proteolysis, tumor suppression, DNA repair and transcription. Despite this, the function of PML bodies is still unknown. Direct and indirect evidence supports the hypothesis that PML bodies interact with specific genes or genomic loci. This includes the finding that the stability of PML bodies is affected by cell stress and changes in chromatin structure. PML bodies also facilitate the transcription and replication of double-stranded DNA viral genomes. Moreover, PML bodies associate with specific regions of high transcriptional activity in the cellular genome. We propose that PML bodies functionally interact with chromatin and are important for the regulation of gene expression.

引用

页码：847 / 854

页数：8

共 87 条

[51] Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization [J].

Kurki, S ;

Latonen, L ;

Laiho, M .

JOURNAL OF CELL SCIENCE, 2003, 116 (19) :3917-3925

[52] Clastosome:: A subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome [J].

Lafarga, M ;

Berciano, MT ;

Pena, E ;

Mayo, I ;

Castaño, JG ;

Bohmann, D ;

Rodrigues, JP ;

Tavanez, JP ;

Carmo-Fonseca, M .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (08) :2771-2782

[53] Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation [J].

Lallemand-Breitenbach, V ;

Zhu, J ;

Puvion, F ;

Koken, M ;

Honoré, N ;

Doubeikovsky, A ;

Duprez, E ;

Pandolfi, PP ;

Puvion, E ;

Freemont, P ;

de Thé, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (12) :1361-1371

[54] Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body [J].

LaMorte, VJ ;

Dyck, JA ;

Ochs, RL ;

Evans, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :4991-4996

[55]

Lombard DB, 2000, CANCER RES, V60, P2331

[56] TRANSACTIVATION OF A HUMAN CYTOMEGALOVIRUS EARLY PROMOTER BY GENE-PRODUCTS FROM THE IMMEDIATE-EARLY GENE IE2 AND AUGMENTATION BY IE1 - MUTATIONAL ANALYSIS OF THE VIRAL-PROTEINS [J].

MALONE, CL ;

VESOLE, DH ;

STINSKI, MF .

JOURNAL OF VIROLOGY, 1990, 64 (04) :1498-1506

[57] THE NUCLEAR LOCATION OF PML, A CELLULAR MEMBER OF THE C3HC4 ZINC-BINDING DOMAIN PROTEIN FAMILY, IS REARRANGED DURING HERPES-SIMPLEX VIRUS-INFECTION BY THE C3HC4 VIRAL PROTEIN ICP0 [J].

MAUL, GG ;

EVERETT, RD .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :1223-1233

[58] Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1 [J].

Maul, GG ;

Ishov, AM ;

Everett, RD .

VIROLOGY, 1996, 217 (01) :67-75

[59] Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress [J].

Maul, GG ;

Yu, E ;

Ishov, AM ;

Epstein, AL .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, 59 (04) :498-513

[60] Deconstructing a disease:: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia [J].

Melnick, A ;

Licht, JD .

BLOOD, 1999, 93 (10) :3167-3215

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