Influence of the HDL receptor SR-BI on lipoprotein - Metabolism and atherosclerosis

被引：198
作者：
Trigatti, BL
Krieger, M
Rigotti, A
机构：
[1] Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago, Chile
[2] McMaster Univ, Dept Biochem, Hamilton, ON, Canada
[3] MIT, Dept Biol, Cambridge, MA USA
来源：
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2003年 / 23卷 / 10期
关键词：
scavenger receptor class B type I; selective uptake; regulation; knockout mouse; coronary heart disease;
D O I：
10.1161/01.ATV.0000091363.28501.84
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles. SR-BI is abundantly expressed in several tissues, including the liver, where its expression is regulated by various mechanisms, including the transcriptional activity of nuclear receptors. The importance of SR-BI in overall HDL cholesterol metabolism and its antiatherogenic activity in vivo has been definitively established by SR-BI gene manipulation in mice. Remarkably, SR-BI/apolipoprotein E double-knockout mice develop complex coronary artery disease, myocardial infarction, and heart failure. Additional studies should help to define the importance of SR-BI in human health and disease.
引用
收藏
页码：1732 / 1738
页数：7
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