Gene profiles within the adult subventricular zone niche: Proliferation, differentiation and migration of neural progenitor cells in the ischemic brain

被引：0
作者：
Zhang, Rui Lan
Zhang, Zheng Gang
Chopp, Michael
机构：
[1] Henry Ford Hosp, Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI 48202 USA
[2] Oakland Univ, Dept Phys, Rochester, MI 48309 USA
来源：
CURRENT MOLECULAR MEDICINE | 2007年 / 7卷 / 05期
关键词：
cerebral ischemia; neurogenesis; gene profiles;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.
引用
收藏
页码：459 / 462
页数：4
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