Usefulness of transbronchial needle aspiration for initial lung cancer staging

被引:5
作者
Soja, Jerzy [1 ]
Szlubowski, Artur [2 ]
Kocon, Piotr [3 ]
Czajkowski, Wojciech [3 ]
Grzanka, Piotr [1 ]
Tomaszewska, Romana [4 ]
Cmiel, Adam [5 ]
Kuzdzal, Jaroslaw [3 ]
机构
[1] Jagiellonian Univ, Sch Med, Dept Med 2, Krakow, Poland
[2] John Paul 2 Hosp, Endoscopy Unit, Krakow, Poland
[3] John Paul 2 Hosp, Dept Thorac Surg, Krakow, Poland
[4] Jagiellonian Univ, Sch Med, Dept Pathol, Krakow, Poland
[5] Univ Sci & Technol, Dept Appl Math, Krakow, Poland
来源
POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE | 2010年 / 120卷 / 7-8期
关键词
mediastinum; non-small cell lung cancer staging; transbronchial needle aspiration; POSITRON-EMISSION-TOMOGRAPHY; ENDOBRONCHIAL ULTRASOUND; EXPERIENCE IMPROVE; DIAGNOSIS; PERFORMANCE; EDUCATION; BIOPSY; CT;
D O I
10.20452/pamw.941
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
INTRODUCTION Besides radiological methods (especially positron emission tomography combined with computed tomography), endoscopic techniques including transbronchial needle aspiration (TBNA) of mediastinal lymph nodes play an important role in lung cancer staging, thus having a significant effect on further patient management. OBJECTIVES The aim of the study was to investigate the diagnostic value of blind TBNA in staging of lung cancer, using systematic mediastinal lymph node dissection (SLND) at thoracotomy as a confirmatory test. PATIENTS AND METHODS Patients with lung cancer and enlarged mediastinal lymph nodes on computed tomography scans underwent TBNA. Non-small cell lung cancer (NSCLC) patients with negative TBNA or with single-level N2 disease underwent thoracotomy with appropriate pulmonary resection and with SLND. RESULTS In 84 lung cancer patients, 166 TBNA were performed. Metastatic lymph node involvement was identified in 57 patients (67.9%). There were 10 patients (11.9%) with small cell lung cancer. Of the 74 NSCLC patients, TBNA revealed metastases in 48 (64.9%). Twenty-four TBNA-negative patients (32.4%) and 4 patients (5.4%) with single-level N2 disease underwent pulmonary resection with SLND. In 8 of 28 operated patients (28.6%), N2 metastatic nodes were identified. The per-patient analysis showed the sensitivity of TBNA to be 81.5%, specificity 100%, accuracy 86.5%, and negative predictive value (NPV) 66.7%. CONCLUSIONS Our results suggest that TBNA may be a useful method for initial NSCLC staging in patients suspected of N2-3 disease. Positive TBNA in 1 station only should not be considered as a true single-level N2 disease, because of a relatively low NPV for TBNA.
引用
收藏
页码:264 / 269
页数:6
相关论文
共 50 条
  • [21] Transbronchial needle aspiration "by the books"
    Kupeli, Elif
    Memis, Leyla
    Ozdemirel, Tugce S.
    Ulubay, Gaye
    Akcay, Sule
    Eyuboglu, Fusun O.
    ANNALS OF THORACIC MEDICINE, 2011, 6 (02) : 85 - 90
  • [22] Endobronchial ultrasound-guided transbronchial needle aspiration for lung cancer staging: early experience in Brazil
    Figueiredo, Viviane Rossi
    Guerreiro Cardoso, Paulo Francisco
    Jacomelli, Marcia
    Demarzo, Sergio Eduardo
    Mejia Palomino, Addy Lidvina
    Rodrigues, Ascedio Jose
    Terra, Ricardo Mingarini
    Pego-Fernandes, Paulo Manoel
    Ribeiro Carvalho, Carlos Roberto
    JORNAL BRASILEIRO DE PNEUMOLOGIA, 2015, 41 (01) : 23 - 30
  • [23] Endobronchial ultrasound with transbronchial needle aspiration: Evaluation of clinical practice
    Basille, D.
    Hybiak, C.
    Dayen, C.
    Toublanc, B.
    Douadi, Y.
    Francois, G.
    Rault, I.
    Andrejak, C.
    Berna, P.
    Jounieaux, V.
    REVUE DES MALADIES RESPIRATOIRES, 2018, 35 (03) : 305 - 312
  • [24] Learning curve of conventional transbronchial needle aspiration
    Tutar, Nuri
    Buyukoglan, Hakan
    Yilmaz, Insu
    Kanbay, Asiye
    Onal, Omer
    Bilgin, Mehmet
    Canoz, Ozlem
    Demir, Ramazan
    Oyak, Fatma Sema
    Gulmez, Inci
    Cetinkaya, Erdogan
    CLINICAL RESPIRATORY JOURNAL, 2014, 8 (01) : 79 - 85
  • [25] RETRACTED: Endobronchial ultrasound-guided transbronchial needle aspiration for lung cancer diagnosis and staging in 179 patients (Retracted Article)
    Bugalho, A.
    Ferreira, D.
    Barata, R.
    Rodrigues, C.
    Dias, S. S.
    Medeiros, F.
    Carreiro, L.
    REVISTA PORTUGUESA DE PNEUMOLOGIA, 2013, 19 (05) : 192 - 199
  • [26] Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Non-Small Cell Lung Cancer Staging
    Kinsey, C. Matthew
    Arenberg, Douglas A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189 (06) : 640 - 649
  • [27] SENSITIVITY OF LINEAR ENDOBRONCHIAL ULTRASONOGRAPHY AND GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION FOR THE IDENTIFICATION OF NODAL METASTASIS IN LUNG CANCER STAGING
    Garcia-Olive, Ignasi
    Monso, Eduard
    Andreo, Felipe
    Sanz, Jose
    Castella, Eva
    Llatjos, Mariona
    de Miguel, Eduardo
    Astudillo, Julio
    ULTRASOUND IN MEDICINE AND BIOLOGY, 2009, 35 (08) : 1271 - 1277
  • [28] Conventional transbronchial needle aspiration: From acquisition to precision
    Kupeli, Elif
    Seyfettin, Pinar
    Tepeoglu, Merih Demirel
    ANNALS OF THORACIC MEDICINE, 2015, 10 (01) : 50 - 54
  • [29] Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Central Lung Parenchymal Lesions
    Verma, Akash
    Jeon, Kyeongman
    Koh, Won-Jung
    Suh, Gee Young
    Chung, Man Pyo
    Kim, Hojoong
    Kwon, O. Jung
    Um, Sang-Won
    YONSEI MEDICAL JOURNAL, 2013, 54 (03) : 672 - 678
  • [30] Efficacy of Convex Probe Endobronchial Ultrasound (CP-EBUS) Assisted Transbronchial Needle Aspiration for Mediastinal Staging in Non-small Cell Lung Cancer Cases with Mediastinal Lymphadenopathy
    Cetinkaya, Erdogan
    Seyhan, Ekrem Cengiz
    Ozgul, Akif
    Gencoglu, Atayla
    Ozgul, Guler
    Cam, Ertan
    Kamiloglu, Emine
    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, 2011, 17 (03) : 236 - 242