Bacterial Nanomachines: The Flagellum and Type III Injectisome

被引：184

作者：

Erhardt, Marc ^{[1
]}

Namba, Keiichi ^{[2
]}

Hughes, Kelly T. ^{[1
]}

机构：

[1] Univ Fribourg, Dept Biol, CH-1700 Fribourg, Switzerland

[2] Osaka Univ, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PROTON MOTIVE FORCE; SALMONELLA-TYPHIMURIUM; SECRETION SYSTEMS; ESCHERICHIA-COLI; BASAL BODY; CRYSTAL-STRUCTURE; EXPORT APPARATUS; PROTEIN DELIVERY; NEEDLE COMPLEX; FLII ATPASE;

D O I：

10.1101/cshperspect.a000299

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The bacterial flagellum and the virulence-associated injectisome are complex, structurally related nanomachines that bacteria use for locomotion or the translocation of virulence factors into eukaryotic host cells. The assembly of both structures and the transfer of extracellular proteins is mediated by a unique, multicomponent transport apparatus, the type III secretion system. Here, we discuss the significant progress that has been made in recent years in the visualization and functional characterization of many components of the type III secretion system, the structure of the bacterial flagellum, and the injectisome complex.

引用

页数：22

共 84 条

[1] Flagellar assembly in Salmonella typhimurium [J].