DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

被引：255

作者：

Aranda, Sergi ^{[1
,2
]}

Laguna, Ariadna ^{[1
,2
]}

de la Luna, Susana ^{[1
,2
,3
]}

机构：

[1] Univ Pompeu Fabra, Ctr Genom Regulat, Barcelona, Spain

[2] Ctr Invest Biomed Red Enfermedades Raras, Barcelona, Spain

[3] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

来源：

FASEB JOURNAL | 2011年 / 25卷 / 02期

关键词：

cell differentiation; cell survival; endocytosis; phosphorylation; TO-EMBRYO TRANSITION; PHOSPHORYLATION-REGULATED KINASE; DOWN-SYNDROME; TRANSCRIPTION FACTOR; CELL-DIVISION; TYROSINE-PHOSPHORYLATION; SUBCELLULAR-LOCALIZATION; SACCHAROMYCES-CEREVISIAE; INHIBITS PROLIFERATION; APOPTOTIC RESPONSE;

D O I：

10.1096/fj.10-165837

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dual-specificity tyrosine-regulated kinases (DYRKs) comprise a family of protein kinases within the CMGC group of the eukaryotic kinome. Members of the DYRK family are found in 4 (animalia, plantae, fungi, and protista) of the 5 main taxa or kingdoms, and all DYRK proteins studied to date share common structural, biochemical, and functional properties with their ancestors in yeast. Recent work on DYRK proteins indicates that they participate in several signaling pathways critical for developmental processes and cell homeostasis. In this review, we focus on the DYRK family of proteins from an evolutionary, biochemical, and functional point of view and discuss the most recent, relevant, and controversial contributions to the study of these kinases.-Aranda, S., Laguna, A., de la Luna, S. DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J. 25, 449-462 (2011). www.fasebj.org

引用

页码：449 / 462

页数：14

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