Isolation and structure elucidation of tsugicolines F-H, novel furosesquiterpenes, and tsugicoline I from the fungus Laurilia tsugicola

Three novel sesquiterpenes of protoilludane origin, tsugicolines F-H (4a-6a), have been isolated from solid cultures of the Basidiomycetae Laurilia tsugicola. Their structures were elucidated by means of chemical correlation and NMR studies; a possible pathway for the formation from the protoilludane derivative tsugicoline A is reported. The furosesquiterpenes 4a and 5a are weakly active on bacteria but inhibited the germination of the water cress Lepidium sativum. A fourth metabolite, the norsesquiterpene tsugicoline I 7, was also isolated from the same fungus. (C) 1998 Elsevier Science Ltd. All rights reserved.