Therapeutic effect of heat-killed Lactobacillus plantarum L-137 on the gut health and growth of broilers

被引:5
|
作者
Thi, Hai Ha Pham [1 ]
Thi, Tuong Vi Phan [2 ]
Huynh, Ninh Pham [2 ]
Doan, Vinh [2 ]
Onoda, Satoru [3 ]
Nguyen, Thanh Luan [4 ]
机构
[1] Nguyen Tat Thanh Univ, NTT Hitech Inst, 298-300A Nguyen Tat Thanh St,Ward 13,Dist 4, Ho Chi Minh City 700000, Vietnam
[2] Inst Anim Sci Southern Vietnam, Dept Anim Nutr & Feedstuffs, Di An, Binh Duong, Vietnam
[3] House Wellness Foods Co, Tokyo, Japan
[4] HUTECH Univ, Dept Technol Sci & Int Affair, 475A Dien Bien Phu St,Ward 25, Ho Chi Minh City 700000, Vietnam
关键词
INFLUENCES CLOSTRIDIUM-PERFRINGENS; NECROTIC ENTERITIS; ANTIMICROBIAL PEPTIDES; BARRIER FUNCTION; INTESTINAL MICROBIOTA; LIQUID METABOLITE; DIETARY AMINES; PERFORMANCE; SUPPLEMENTATION; MORPHOLOGY;
D O I
10.1016/j.actatropica.2022.106537
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Although some studies on the effects of para-probiotics on the immune system and intestinal health have been conducted independently of research on antibiotics ass growth promoters. This study investigated the effects of heat-killed Lactobacillus plantarum L-137 (L-137) and antibiotics as preventive and/or therapeutic substances for broilers against subclinical necrotic enteritis caused by Clostridium perfringens (CP). In total, 300 1-day-old broilers (46.13 +/- 1.38 g) were randomly stocked at 10 birds pen-1 in five replicates and divided into six groups, namely T1 and T2, positive and negative control of CP challenge; T3 and T4, prevention with basal diet plus 10 and 50 mg/kg L-137; T5 and T6, prevention and treatment with basal diet plus 50 mg/kg of L-137 and bacitracin at 50 ppm, respectively. Broilers administered L137 in T4, T5 and bacitracin in T6 showed an improved (p < 0.05) villus height/crypt depth ratio than control groups, suggesting that it might significantly boost growth performance. In contrast to bacitracin, a high dosage of L-137 significantly increased (p < 0.05) the spleen index value and the cytokine levels, as well as the expression of intestinal beta-defensin genes on day 28. During the 42-day production period, broilers in T4 and T5 showed a significantly enhanced (p < 0.05) expression of cytokines, AvBD-1 and AvBD-7 on day 42 compared to the control and bacitracin groups. In particular, broilers given the L-137 diets demonstrated no cumulative mortality following CP exposure, compared to a 2% mortality in T6. Our findings provide insight into eco-friendly alternatives to antibiotics for maximizing growth performance, feed efficiency and long-term disease protection in chickens; however, this has to be proven in larger-scale commercial experiments.
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页数:10
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