Transient Impact of Dysglycemia on Sputum Conversion among Smear-Positive Tuberculosis Patients in a Tertiary Care Facility in Ghana

被引:5
作者
Yorke, Ernest [1 ]
Boima, Vincent [1 ]
Dey, Ida Dzifa [1 ]
Amissah-Arthur, Maame-Boatemaa [1 ]
Ganu, Vincent [2 ]
Amaning-Kwarteng, Ernest [2 ]
Tetteh, John [1 ,2 ]
Charles Mate-Kole, C. [1 ,2 ]
机构
[1] Univ Ghana, Accra, Greater Accra, Ghana
[2] Korle Bu Teaching Hosp, Accra, Greater Accra, Ghana
来源
CLINICAL MEDICINE INSIGHTS-CIRCULATORY RESPIRATORY AND PULMONARY MEDICINE | 2021年 / 15卷
关键词
Tuberculosis; smear Positive; dysglycemia; sputum Conversion; transient; TYPE-2; DIABETES-MELLITUS; PULMONARY TUBERCULOSIS; ASSOCIATION; RATIO;
D O I
10.1177/11795484211039830
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
BACKGROUND: Apart from increasing the risk of tuberculosis (TB), diabetes may be associated with more severe disease and lower rates of sputum conversion among TB patients. METHODS: We conducted a baseline cross-sectional study with a longitudinal follow-up of newly diagnosed smear-positive TB patients for 6 months. Sputum conversion rates between those with dysglycemia and those without were compared at 2 months (end of the intensive phase) and 6 months (end of the treatment). Descriptive statistics and logistic regression were computed to assess factors associated with dysglycemia as well as sputum conversion. RESULTS: A significantly higher proportion of normoglycemic patients had negative sputum compared with those with dysglycemia (83% vs 67%, P-value < .05) at 2 months but not at 6 months (87% vs 77%, P-value > .05). After controlling for age group and adjusting for other covariates, patients with dysglycemia were 66% less likely to convert sputum than those with normoglycemia. Females were at least 7 times more likely than males and those with high waist-to-hip ratio (WHR) of 88% were less likely compared with those with low WHR for sputum conversion at 2 months, respectively. At 6 months, females (compared with males) and those with high WHR (compared with those with normal WHR) were at over 9 times increased odds and 89% less likely for sputum conversion, respectively. CONCLUSION: A significantly lower proportion of smear-positive TB patients with dysglycemia converted to smear negative after 2 months of treatment but not at the end of the treatment, thus suggesting a transient impact of dysglycemia on sputum conversion.
引用
收藏
页数:8
相关论文
共 42 条
  • [31] Type 2 diabetes and tuberculosis in a dynamic bi-national border population
    Restrepo, B. I.
    Fisher-Hoch, S. P.
    Crespo, J. G.
    Whitney, E.
    Perez, A.
    Smith, B.
    McCormick, J. B.
    [J]. EPIDEMIOLOGY AND INFECTION, 2007, 135 (03) : 483 - 491
  • [32] Sacks DB, 2002, CLIN CHEM, V48, P436, DOI 10.2337/dc11-9998
  • [33] Salpea P, 2019, DRCP, V9th, P1
  • [34] ASSOCIATION OF WAIST-HIP RATIO WITH DIABETES-MELLITUS - STRENGTH AND POSSIBLE MODIFIERS
    SCHMIDT, MI
    DUNCAN, BB
    CANANI, LH
    KAROHL, C
    CHAMBLESS, L
    [J]. DIABETES CARE, 1992, 15 (07) : 912 - 914
  • [35] Singla R, 2006, INT J TUBERC LUNG D, V10, P74
  • [36] Singla R, 2003, INT J TUBERC LUNG D, V7, P58
  • [37] Diabetes and the risk of tuberculosis: a neglected threat to public health?
    Stevenson, Catherine R.
    Critchley, Julia A.
    Forouhi, Nita G.
    Roglic, Gojka
    Williams, Brian G.
    Dye, Christopher
    Unwin, Nigel C.
    [J]. CHRONIC ILLNESS, 2007, 3 (03) : 228 - 245
  • [38] Tsukaguchi K, 1992, Kekkaku, V67, P755
  • [39] Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: A meta-analysis
    Vazquez, Gabriela
    Duval, Sue
    Jacobs, David R., Jr.
    Silventoinen, Karri
    [J]. EPIDEMIOLOGIC REVIEWS, 2007, 29 : 115 - 128
  • [40] Wilson RM., 1991, Textbook of Diabetes, P813