Metal nanoparticles: understanding the mechanisms behind antibacterial activity

被引：1779

作者：

Slavin, Yael N. ^{[1
]}

Asnis, Jason ^{[2
]}

Hafeli, Urs O. ^{[2
]}

Bach, Horacio ^{[1
]}

机构：

[1] Univ British Columbia, Div Infect Dis, Dept Med, 410-2660 Oak St, Vancouver, BC V6H 3Z6, Canada

[2] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2017年 / 15卷

关键词：

Nanoparticles; Metals; ROS; Mechanism of defense; Bacteria; Transcriptomics; Proteomics; Gene regulation; Antibacterial resistance; BIOSYNTHESIZED SILVER NANOPARTICLES; ESCHERICHIA-COLI; ANTIMICROBIAL ACTIVITY; OXIDE NANOPARTICLES; TIO2; NANOPARTICLES; STAPHYLOCOCCUS-AUREUS; STRESS-RESPONSE; ELECTROPHORETIC MOBILITY; RESPIRATORY-CHAIN; TOXICITY;

D O I：

10.1186/s12951-017-0308-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.

引用

页数：20

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