Association of metabolic syndrome and 25-hydroxyvitaminD with cognitive impairment among elderly Koreans

被引：19

作者：

Lee, Eun Young ^{[1
]}

Lee, Su Jin ^{[2
,9
]}

Kim, Kyoung Min ^{[10
]}

Yun, Young Mi ^{[3
]}

Song, Bo Mi ^{[3
,7
]}

Kim, Jong Eun ^{[4
,7
]}

Kim, Hyeon Chang ^{[3
,5
]}

Rhee, Yumie ^{[6
]}

Youm, Yoosik ^{[8
]}

Kim, Chang Oh ^{[4
]}

机构：

[1] Catholic Univ Korea, Seoul St Marys Hosp, Div Endocrinol & Metab, Dept Internal Med,Coll Med, Seoul, South Korea

[2] Yonsei Univ, Dept Med, Grad Sch Med, Seoul, South Korea

[3] Yonsei Univ, Cardiovasc & Metab Dis Etiol Res Ctr, Coll Med, Seoul, South Korea

[4] Yonsei Univ, Dept Internal Med, Div Geriatr, Coll Med, 50-1 Yonsei Ro, Seoul 120752, South Korea

[5] Yonsei Univ, Dept Prevent Med, Coll Med, Seoul, South Korea

[6] Yonsei Univ, Div Endocrinol & Metab, Coll Med, Dept Internal Med, Seoul, South Korea

[7] Yonsei Univ, Dept Publ Hlth, Grad Sch, Seoul, South Korea

[8] Yonsei Univ, Dept Sociol, Seoul, South Korea

[9] Natl Hlth Insurance Serv Ilsan Hosp, Div Endocrinol, Dept Internal Med, Goyang, South Korea

[10] Seoul Natl Univ, Div Endocrinol & Metab, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

来源：

GERIATRICS & GERONTOLOGY INTERNATIONAL | 2017年 / 17卷 / 07期

关键词：

cognitive impairment; elderly; metabolic syndrome; vitaminD; VITAMIN-D DEFICIENCY; OLDER WOMEN; DECLINE; ADULTS; RISK;

D O I：

10.1111/ggi.12826

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

AimMetabolic syndrome and vitaminD deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitaminD (25[OH]D) levels on cognitive function in older adults. MethodsWe studied 2940 participants aged 65years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment PanelIII criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25-49, 50-74 and 75nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. ResultsParticipants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61-5.80) when compared with those with no metabolic syndrome and high 25(OH)D. ConclusionsMetabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069-1075.

引用

页码：1069 / 1075

页数：7

共 30 条

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