Genetically Modified Pigs as Organ Donors for Xenotransplantation

被引：103

作者：

Hryhorowicz, Magdalena ^{[1
]}

Zeyland, Joanna ^{[1
]}

Slomski, Ryszard ^{[1
,2
]}

Lipinski, Daniel ^{[1
]}

机构：

[1] Poznan Univ Life Sci, Dept Biochem & Biotechnol, Dojazd 11, PL-60632 Poznan, Poland

[2] Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60101 Poznan, Poland

来源：

MOLECULAR BIOTECHNOLOGY | 2017年 / 59卷 / 9-10期

关键词：

Transgenic pigs; Genetic engineering; Xenotransplantation; Genetically modified pigs; Genome modifications; PORCINE ENDOGENOUS RETROVIRUSES; LONG-TERM SURVIVAL; TRANSGENIC EXPRESSION; ENDOTHELIAL-CELLS; KNOCKOUT PIGS; XENOGRAFT REJECTION; HEART-TRANSPLANTATION; HUMAN THROMBOMODULIN; PROVIDES PROTECTION; HEME OXYGENASE-1;

D O I：

10.1007/s12033-017-0024-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growing shortage of available organs is a major problem in transplantology. Thus, new and alternative sources of organs need to be found. One promising solution could be xenotransplantation, i.e., the use of animal cells, tissues and organs. The domestic pig is the optimum donor for such transplants. However, xenogeneic transplantation from pigs to humans involves high immune incompatibility and a complex rejection process. The rapid development of genetic engineering techniques enables genome modifications in pigs that reduce the cross-species immune barrier.

引用

页码：435 / 444

页数：10

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