Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis

[1] Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis [J]. CELL DEATH AND DIFFERENTIATION, 2007, 14 (05) : 1060 - 1062

[2] Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload-Induced Cardiac Failure [J]. CIRCULATION, 2011, 123 (04) : 391 - 399

[3] Akt1 is required for physiological cardiac growth [J]. CIRCULATION, 2006, 113 (17) : 2097 - 2104

[4] PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth [J]. MOLECULAR CELL, 2005, 18 (01) : 13 - 24

[5] The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110α) pathway [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (06) : 4782 - 4793

[6] Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy [J]. CARDIOVASCULAR RESEARCH, 2015, 105 (02) : 160 - 170

[7] Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) : 2108 - 2118

[8] Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (19) : 6899 - 6911

[9] Sinko W, 2012, METHODS MOL BIOL, V819, P561, DOI 10.1007/978-1-61779-465-0_33

[1] Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis [J]. CELL DEATH AND DIFFERENTIATION, 2007, 14 (05) : 1060 - 1062

[2] Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase γ Activity in Pressure Overload-Induced Cardiac Failure [J]. CIRCULATION, 2011, 123 (04) : 391 - 399

[3] Akt1 is required for physiological cardiac growth [J]. CIRCULATION, 2006, 113 (17) : 2097 - 2104

[4] PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth [J]. MOLECULAR CELL, 2005, 18 (01) : 13 - 24

[5] The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110α) pathway [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (06) : 4782 - 4793

[6] Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy [J]. CARDIOVASCULAR RESEARCH, 2015, 105 (02) : 160 - 170

[7] Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (08) : 2108 - 2118

[8] Discovery of Small Molecule Inhibitors of the PH Domain Leucine-Rich Repeat Protein Phosphatase (PHLPP) by Chemical and Virtual Screening [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (19) : 6899 - 6911

[9] Sinko W, 2012, METHODS MOL BIOL, V819, P561, DOI 10.1007/978-1-61779-465-0_33