Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications

被引：9

作者：

Bertok, Tomas ^{[1
,2
]}

Bertokova, Aniko ^{[1
,2
]}

Hroncekova, Stefania ^{[2
]}

Chocholova, Erika ^{[2
]}

Svecova, Natalia ^{[2
]}

Lorencova, Lenka ^{[2
]}

Kasak, Peter ^{[3
]}

Tkac, Jan ^{[1
,2
]}

机构：

[1] Glycanost Ltd, Dubrayska Cesta 9, Bratislava 84538, Slovakia

[2] Slovak Acad Sci, Inst Chem, Dubrayska Cesta 9, Bratislava 84538, Slovakia

[3] Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar

来源：

CHEMOSENSORS | 2021年 / 9卷 / 08期

关键词：

prostate cancer; biosensors; biomarkers; glycans; lectins; aptamers; molecularly imprinted polymers; MOLECULARLY IMPRINTED POLYMER; HYDROGEN-PEROXIDE; ELECTROCHEMICAL DETECTION; GRAPHENE OXIDE; SARCOSINE DETERMINATION; CIRCULATING MICRORNA; SENSITIVE DETECTION; FLUORESCENT-PROBE; ACID-PHOSPHATASE; EARLY-DIAGNOSIS;

D O I：

10.3390/chemosensors9080205

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about PCa aetiology, alternative biomarkers available for PCa diagnostics besides prostate specific antigen and their biosensing. In particular, low molecular mass biomolecules (ions and metabolites) and high molecular mass biomolecules (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.

引用

页数：33

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