First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist

被引：41

作者：

Wagner, GK

Black, S

Guse, AH

Potter, BVL

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Wolfson Lab Med Chem, Bath BA2 7AY, Avon, England

[2] Univ Hamburg, Hosp Eppendorf, Inst Med Biochem & Mol Biol Cellular Signal Trans, D-20246 Hamburg, Germany

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 15期

关键词：

D O I：

10.1039/b305660k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nicotinamide 8-Br-hypoxanthine dinucleotide (8-BrNHD+) was cyclised at the N1 position by the ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose (8-Br-N-1-cIDPR), a novel membrane-permeant agonist of Ca2+ release in human T cells.

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收藏

页码：1944 / 1945

页数：2

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