Cu-facilitated C-O bond formation using N-hydroxyphthalimide:: Efficient and selective functionalization of benzyl and allylic C-H bonds

被引：155

作者：

Lee, Ji Min

Park, Eun Ju

Cho, Seung Hwan

Chang, Sukbok ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 25期

关键词：

D O I：

10.1021/ja8031218

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient protocol for the benzyl or allylic C-H functionalization of simple hydrocarbons has been developed using stoichiometric amounts of N-hydroxyphthalimide and Phl(OAc)(2) in the presence of CuCl catalyst. The reaction was revealed to proceed via a radical pathway, in which phthalimide N-oxyl (PINO) radical plays a dual role, serving as a catalytic hydrogen abstractor from hydrocarbons as well as a stoichiometric reagent to couple with the resultant alkyl radicals.

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页码：7824 / +

页数：3

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