Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

被引：44

作者：

Chuang, Pei-Hsuan ^{[1
]}

Hsieh, Pei-Wen ^{[2
]}

Yang, Yu-Liang ^{[3
]}

Hua, Kuo-Feng ^{[3
]}

Chang, Fang-Rong ^{[1
]}

Shiea, Jentaie ^{[4
]}

Wu, Shih-Hsiung ^{[3
]}

Wu, Yang-Chang ^{[1
,4
,5
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

[4] Kaohsiung Med Univ, Natl Sun Yat Sen Univ, Joint Res Ctr, Kaohsiung 804, Taiwan

[5] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 08期

关键词：

D O I：

10.1021/np8001282

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new cyclopeptides, cyclomontanins A-D (1-4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of I was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.

引用

页码：1365 / 1370

页数：6

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