Five Genome Sequences of Subspecies B1 Human Adenoviruses Associated with Acute Respiratory Disease

被引:19
作者
Dehghan, Shoaleh [1 ]
Liu, Elizabeth B. [1 ]
Seto, Jason [1 ]
Torres, Sarah F. [2 ]
Hudson, Nolan R. [2 ]
Kajon, Adriana E. [3 ]
Metzgar, David [4 ]
Dyer, David W. [5 ]
Chodosh, James [6 ]
Jones, Morris S. [7 ]
Seto, Donald [1 ]
机构
[1] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA
[2] David Grant USAF Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA
[3] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA
[4] USN, Dept Resp Dis Res, Hlth Res Ctr, San Diego, CA 92106 USA
[5] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA
[6] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Howe Lab, Boston, MA 02114 USA
[7] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab, Richmond, CA 94804 USA
关键词
COMPUTATIONAL ANALYSIS; RECOMBINATION; INFECTION; GENE;
D O I
10.1128/JVI.06593-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Five genomes of human subspecies B1 adenoviruses isolated from cases of acute respiratory disease have been sequenced and archived for reference. These include representatives of two prevalent genomic variants of HAdV-7, i.e., HAdV-7h and HAdV7d2. The other three are HAdV-3/16, HAdV-16 strain E26, and HAdV-3+7 strain Takeuchi. All are recombinant genomes. Genomics and bioinformatics provide detailed views into the genetic makeup of these pathogens and insight into their molecular evolution. Retrospective characterization of particularly problematic older pathogens such as HAdV-7h (1987) and intriguing isolates such as HAdV-3+7 strain Takeuchi (1958) may provide clues to their phenotypes and serology and may suggest protocols for prevention and treatment.
引用
收藏
页码:635 / 636
页数:2
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