Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity-associated Insulin Resistance and Hypertension

被引：127

作者：

De Boer, Michiel P. ^{[1
]}

Meijer, Rick I. ^{[1
]}

Wijnstok, Nienke J. ^{[1
]}

Jonk, Amy M. ^{[2
]}

Houben, Alphons J. ^{[2
]}

Stehouwer, Coen D. ^{[4
]}

Smulders, Yvo M. ^{[1
]}

Eringa, Etto C. ^{[3
]}

Serne, Erik H. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, NL-1007 MB Amsterdam, Netherlands

[2] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Physiol, NL-1007 MB Amsterdam, Netherlands

[4] Acad Hosp Maastricht, Maastricht, Netherlands

来源：

MICROCIRCULATION | 2012年 / 19卷 / 01期

关键词：

microvascular dysfunction; insulin resistance; hypertension; diabetes; obesity; NECROSIS-FACTOR-ALPHA; RENIN-ANGIOTENSIN SYSTEM; MEDIATED CAPILLARY RECRUITMENT; FOREARM GLUCOSE-UPTAKE; RAT SKELETAL-MUSCLE; ADIPOSE-TISSUE; PHYSIOLOGICAL HYPERINSULINEMIA; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;

D O I：

10.1111/j.1549-8719.2011.00130.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intertwined epidemics of obesity and related disorders such as hypertension, insulin resistance, type 2 diabetes, and subsequent cardiovascular disease pose a major public health challenge. To meet this challenge, we must understand the interplay between adipose tissue and the vasculature. Microvascular dysfunction is important not only in the development of obesity-related target-organ damage but also in the development of cardiovascular risk factors such as hypertension and insulin resistance. The present review examines the role of microvascular dysfunction as an explanation for the associations among obesity, hypertension, and impaired insulin-mediated glucose disposal. We also discuss communicative pathways from adipose tissue to the microcirculation.

引用

页码：5 / 18

页数：14

共 125 条

[1] Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease [J].

Ahlborg, Gunvor ;

Shemyakin, Alexey ;

Bohm, Felix ;

Gonon, Adrian ;

Pernow, John .

DIABETES CARE, 2007, 30 (03) :591-596

[2] Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells [J].

Andreozzi, F ;

Laratta, E ;

Sciacqua, A ;

Perticone, F ;

Sesti, G .

CIRCULATION RESEARCH, 2004, 94 (09) :1211-1218

[3] Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality [J].

Antonios, TFT ;

Singer, DRJ ;

Markandu, ND ;

Mortimer, PS ;

MacGregor, GA .

HYPERTENSION, 1999, 34 (04) :655-658

[4] Protein kinase C θ activation induces insulin-mediated constriction of muscle resistance arteries [J].

Bakker, Wineke ;

Sipkema, Pieter ;

Stehouwer, Coen D. A. ;

Serne, Erik H. ;

Smulders, Yvo M. ;

van Hinsbergh, Victor W. M. ;

Eringa, Etto C. .

DIABETES, 2008, 57 (03) :706-713

[5] HEMODYNAMIC ACTIONS OF INSULIN [J].

BARON, AD .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (02) :E187-E202

[6] The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action [J].

Barrett, E. J. ;

Eggleston, E. M. ;

Inyard, A. C. ;

Wang, H. ;

Li, G. ;

Chai, W. ;

Liu, Z. .

DIABETOLOGIA, 2009, 52 (05) :752-764

[7] Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle [J].

Bonadonna, RC ;

Saccomani, MP ;

Del Prato, S ;

Bonora, E ;

DeFronzo, RA ;

Cobelli, C .

CIRCULATION, 1998, 98 (03) :234-241

[8] Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): Implication of macrophages resident in the AT [J].

Bruun, JM ;

Lihn, AS ;

Pedersen, SB ;

Richelsen, B .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (04) :2282-2289

[9] ANGIOTENSIN-II INCREASES GLUCOSE-UTILIZATION DURING ACUTE HYPERINSULINEMIA VIA A HEMODYNAMIC MECHANISM [J].

BUCHANAN, TA ;

THAWANI, H ;

KADES, W ;

MODRALL, JG ;

WEAVER, FA ;

LAUREL, C ;

POPPITI, R ;

XIANG, A ;

HSUEH, W .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (02) :720-726

[10] Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients [J].

Cardillo, C ;

Campia, U ;

Iantorno, M ;

Panza, JA .

HYPERTENSION, 2004, 43 (01) :36-40

← 1 2 3 4 5 6 7 8 9 10 →